Bifurcated Rhodaelectro-catalyzed C−H Activation for the Synthesis of Pyrroles and Lactones  

作　　者：Simon L.Homölle Maximilian Stangier fraim Reyes Lutz Ackermann 

机构地区：[1]Institut für Organische und Biomolekulare Chemie,Georg-August-Universität Göttingen,37077 Göttingen,Germany [2]University of the Basque Country(UPV/EHU),48940 Leioa,Bizkaia,Spain [3]DZHK(German Centre for Cardiovascular Research),10785 Berlin,Germany

出　　处：《Precision Chemistry》2023年第6期382-387,共6页精准化学（英文）

基　　金：Generous support from ERC Advanced Grant 101021358 and the DFG Gottfried Wilhelm Leibniz award(L.A.)is gratefully acknowledged.E.R.thanks the Basque Government(Grupos IT1558-22)for financial support.

摘　　要：While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly of heteroaromatic motives,electrochemical C(sp2)−H activations of alkenes remain scarce.Herein,a strategy for the rhodaelectro-catalyzed function-alization of enamides is presented for the efficient construction of pyrroles using electricity as a sustainable oxidant.Moreover,the tuning of the solvent system allowed a fascinating switch in chemoselectivity,which is not possible with traditionally used chemical oxidants,giving rise to lactone architectures.The rhoda-electrocatalysis features a broad scope as well as high regio-and chemoselectivities.

关 键 词：C−H activation RHODIUM BIFURCATED electrochemistry sustainability PYRROLE LACTONE 

分 类 号：O62[理学—有机化学]