肠-肝轴:肠道微生物稳态与肝细胞癌  

Gut-liver axis:Intestinal microbial homeostasis and hepatocellular carcinoma

作　　者：周荃 蔡春琳 李金强 ZHOU Quan;CAI Chunlin;LI Jinqiang(Department of Infectious Diseases,The First Hospital of Changsha,Changsha 410000,China;Department of Hospital Infection Management,The First Hospital of Changsha,Changsha 410000,China)

机构地区：[1]长沙市第一医院感染科,长沙410000 [2]长沙市第一医院医院感染管理科,长沙410000

出　　处：《临床肝胆病杂志》2023年第11期2710-2717,共8页Journal of Clinical Hepatology

基　　金：湖南省卫生健康委科研计划项目(20200163,202103081037)。

摘　　要：肠道微生物群在维持肝脏代谢稳态中扮演重要角色,其通过参与胆汁酸代谢影响肝细胞癌的发生发展。“肠-肝轴”在肝脏疾病发病机制中占据举足轻重的地位,通过纠正肠道生态失衡以恢复正常胆汁酸水平,可能是阻止肝细胞癌进展的有效方法之一。本文总结了胆汁酸受体影响肝细胞癌的相关机制以及最新治疗靶点,旨在为早期防治肝癌提供参考依据。Intestinal microbiota plays an important role in maintaining liver metabolic homeostasis and affects the development and progression of hepatocellular carcinoma by participating in bile acid metabolism.Gut-liver axis plays an important role in the pathogenesis of liver diseases,and it might be one of the effective methods to prevent the progression of hepatocellular carcinoma by correcting intestinal ecological imbalance to restore normal bile acid level.This article summarizes the mechanism of bile acid receptor affecting hepatocellular carcinoma and the latest therapeutic targets,in order to provide a reference for the early prevention and treatment of hepatocellular carcinoma.

关 键 词：癌 肝细胞 胃肠道微生物组 胆汁酸类和盐类 

分 类 号：R735.7[医药卫生—肿瘤]