淀粉样蛋白在肝脏中的生理病理作用  

The physiological and pathological role of amyloid protein in the liver

作　　者：宗也凯 刘江凯[2] ZONG Yekai;LIU Jiangkai(Department of Hepatology and Spleen-Stomach,The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450008,China;Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China)

机构地区：[1]河南中医药大学第一临床医学院脾胃肝胆科,郑州450008 [2]河南中医药大学第一附属医院脾胃肝胆科,郑州450008

出　　处：《临床肝胆病杂志》2023年第11期2730-2737,共8页Journal of Clinical Hepatology

基　　金：国家自然科学基金(U1504825);河南省中医药拔尖人才项目(豫卫中医函2021-15)。

摘　　要：淀粉样蛋白被用来描述因蛋白质错误折叠而形成的纤维状聚集体,它与一系列淀粉样变性疾病有关。当淀粉样蛋白沉积在肝脏,就会导致肝淀粉样变性,从而诱发相关病理改变影响肝脏正常生理功能,但这一疾病少有报道且临床常常被忽视。本文主要讨论了淀粉样蛋白在肝脏中的生理病理作用及机制,以便于加深对淀粉样蛋白相关疾病的理解并为相关研究和临床治疗提供一定参考。Amyloid protein(AP)is used to describe the fibrous aggregates that form when proteins are misfolded,and it is associated with a series of amyloidosis diseases.When AP is deposited in the liver,it will lead to liver amyloidosis,thereby inducing related pathological changes that affect the normal physiological function of the liver;however,this disease is rarely reported and often neglected in clinical practice.This article reviews the physiological and pathological effects and mechanisms of AP in the liver,so as to improve the understanding of AP-related diseases and provide a reference for related research and clinical treatment.

关 键 词：淀粉样蛋白 淀粉样变性 肝疾病 病理过程 

分 类 号：R575[医药卫生—消化系统]