小胶质细胞-星形胶质细胞的交互作用及其介导的神经炎症在阿尔茨海默病中的研究进展  

Progress in microglia-astrocyte interactions and their mediation of neuroinflammation in Alzheimer’s disease

作　　者：胡鑫 汪蒨 张晨曦 郑慧慧 李鹏洋 赵红晔 邓凤春[1] HU Xin;WANG Qian;ZHANG Chenxi;ZHENG Huihui;LI Pengyang;ZHAO Hongye;DENG Fengchun(School of Basic Medicine,Qiqihar Medical University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院基础医学院,黑龙江齐齐哈尔161006

出　　处：《中国比较医学杂志》2023年第11期142-149,共8页Chinese Journal of Comparative Medicine

基　　金：国家级大学生创新创业训练计划项目(202211230063)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种侵袭性神经退行性疾病,其发病原因迄今未清。神经炎症是中枢神经系统(central nervous system,CNS)中由小胶质细胞和星形胶质细胞激活的一种慢性炎症反应,与多种炎症因子的释放和血脑屏障(blood brain barrier,BBB)的破坏密切相关。研究表明,神经炎症是继β-淀粉样蛋白(amyloid-βprotein,Aβ)沉积和神经原纤维缠结(neurofibrillary tangles,NFTs)后AD的第三大病理改变。本文总结了小胶质细胞-星形胶质细胞的交互作用,并对其在神经炎症和AD中的作用进行整理和讨论,以期为AD的发病机制及防治研究提供理论支持和实验参考。Alzheimer’s disease(AD)is an invasive neurodegenerative disease,the cause of which is still unknown.Neuroinflammation is a chronic inflammatory response activated by microglia and astrocytes in the central nervous system that is closely related to the release of many inflammatory factors and the destruction of the blood-brain barrier.Studies have shown that neuroinflammation is the third largest pathological change in AD afterβ-amyloid deposition and neurofibrillary tangles.In this paper,the information available on microglia,astrocytes and their interactions is summarized.The roles of these cells in neuroinflammation and AD are presented and discussed to provide a theoretical and experimental reference for the pathogenesis,prevention,and treatment of AD.

关 键 词：神经炎症 小胶质细胞 星形胶质细胞 阿尔茨海默病 

分 类 号：R-33[医药卫生]