亚肺叶切除治疗对NSCLC患者生存率及肿瘤复发的影响  

The Effect of Subpulmonary Lobectomy Treatment on Survival Rate and Tumor Recurrence in NSCLC Patients

作　　者：骆俊龙 包传恩 胡蒙 张淑云 林美旺 毛俊鸿 孙茂淋 郭明 LUO Junlong;BAO Chuan'en;HU Meng;ZHANG Shuyun;LIN Meiwang;MAO Junhong;SUN Maolin;GUO Ming(Department of Cardiothoracic Surgery,Army 73rd Group Military Hospital,Xiamen Fujian 361000,China)

机构地区：[1]陆军第七十三集团军医院心胸外科,福建厦门361000

出　　处：《中国卫生标准管理》2023年第21期88-91,共4页China Health Standard Management

摘　　要：目的 分析亚肺叶切除治疗对非小细胞肺癌(non-small cell lung cancer,NSCLC)患者生存率及肿瘤复发情况的影响。方法 选取陆军第七十三集团军医院2020年1月—2022年1月收治的300例NSCLC患者,按照不同的治疗方式分为两组,对照组(n=145)接受肺叶切除术治疗,研究组(n=155)则接受亚肺叶切除手术治疗。比较两组的围手术期相关指标、血清肿瘤标志物、术后并发症、生存率及肿瘤复发情况。结果 研究组的手术时间、住院时间均明显短于对照组(P<0.05),而术中出血量、术后并发症则明显少于对照组(P<0.05)。与术前相比,两组术后7 d的癌胚抗原(carcinoembryonic antigen,CEA)、细胞角蛋白19片段(cytokeratin 19 fragment,CYFRA21-1)水平组内比较,差异无统计学意义(P> 0.05);两组术前、术后7 d的CEA、CYFRA21-1水平组间比较,差异无统计学意义(P> 0.05)。术后1年,两组的生存率、肿瘤复发率比较,差异无统计学意义(P> 0.05)。结论 选择亚肺叶切除手术治疗NSCLC患者能使手术创伤有效减轻,术后并发症明显减少,促进患者术后及早康复,同时不会影响患者预后,治疗效果显著,具有较高的安全性,此文的研究结果为非小细胞肺癌患者手术切除治疗后期标准制定提供了借鉴内容。Objective T0 analyze the impact of sub lobectomy treatment on survival rate and tumor recurrence in non-small cell lung cancer(NSCLC)patients.Methods A total of 300 patients with NSCLC admitted from January 2020 to January 2022 in Army 73rd Group Military Hospital of the Army were selected and divided into two groups according to different treatment methods.The control group(n=145)received lobectomy,while the study group(n=155)received sub lobectomy.Perioperative related indicators,serum tumor markers,postoperative complications,the survival rate and tumor recurrence between the two groups were compared.Results The surgical time and hospitalization time of the study group were significantly shorter than those of the control group(P<0.05),while the intraoperative bleeding and postoperative complications were significantly lower than those of the control group(P<0.05).Compared with preoperative,there was no statistically significant difference in the levels of carcinoembryonic antigen(CEA)and cytokeratin 19 fragment(CYFRA21-1)between the two groups at 7 days after surgery(P>0.05).There was no statistically significant difference in CEA and CYFRA21-1 levels between the control group and the study group before and 7 days after surgery(P>0.05).Conclusion Choosing sub lobectomy surgery for NSCLC patients can effectively reduce surgical trauma,significantly reduce postoperative complications,promote early postoperative recovery,and do not affect patient prognosis.The treatment effect is significant and has high safety.The research results of this article provide reference content for the formulation of late stage standards for surgical resection treatment of non-small cell lung cancer patients.

关 键 词：亚肺叶切除手术 非小细胞肺癌 生存率 肿瘤复发 癌胚抗原 并发症 

分 类 号：R734[医药卫生—肿瘤]