人参养荣汤对小细胞肺癌化疗后骨髓抑制患者疗效的影响  

Effect of Ginseng Yangrong Decoction on the therapeutic effect of patients with bone marrow suppression after chemotherapy of small cell lung cancer

作　　者：王振强 王洪亮 张庆江 陈晶晶 李小江[2] 赵芳 赵阳 董雪珊 周雍明[3] WANG Zhen-qiang;WANG Hong-liang;ZHANG Qing-jiang(Department of Traditional Chinese Medicine,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Hebei College of Traditional Chinese Medicine,Cangzhou 061000,China)

机构地区：[1]河北中医学院附属沧州中西医结合医院中医内科,沧州061000 [2]天津中医药大学第一附属医院中医内科,天津300193 [3]中国中医科学院广安门医院中医内科,北京100000

出　　处：《中国中西医结合外科杂志》2023年第6期793-797,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局课题(2017279)。

摘　　要：目的:探讨人参养荣汤对小细胞肺癌化疗后骨髓抑制患者疗效的影响。方法:选取本院2019年5月—2020年12月收治的小细胞肺癌化疗后骨髓抑制患者120例,按照随机数字表法分为治疗组(60例)和对照组(60例),对照组给予西药治疗,治疗组在对照组基础上加用人参养荣汤治疗,比较两组患者免疫指标[肿瘤坏死因子-α(TNF-α)、可溶性白细胞介素-2受体(sIL-2R)]、卡氏量表(KPS)及健康调查简表(SF-36)评分、血清白蛋白水平、白细胞计数、中性粒细胞计数、血小板计数、毒副反应发生率及临床疗效。结果:与治疗前比较,治疗后,两组患者KPS评分、SF-36评分、TNF-α、血清白蛋白水平、白细胞计数、中性粒细胞计数、血小板计数均升高(P<0.05),且治疗组高于对照组(P<0.05);sIL-2R水平降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗组毒副反应发生率为31.67%,对照组毒副反应发生率为73.33%,治疗组低于对照组(P<0.05);治疗组总有效率(76.67%)高于对照组(50.00%)(P<0.05)。结论:人参养荣汤用于小细胞肺癌化疗后骨髓抑制患者,能够改善患者免疫功能及临床症状,提高生活质量,降低毒副反应发生率,增强疗效。Objective To explore the effect of Ginseng Yangrong Decoction on the curative effect of patients with bone marrow suppression after chemotherapy of small cell lung cancer.Methods A total of 120 patients with bone marrow suppression after chemotherapy for small cell lung cancer in our hospital from May 2019 to December 2020 were selected and randomly divided into a treatment group(60 cases)and a control group(60 cases)according to the random number table method.The control group was treated with western medicine,and the treatment group was treated with Ginseng Yangrong Decoction on the basis of the control group.The immune indicators[tumor necrosis factor-α(TNF-α),soluble interleukin-2 receptor(sIL-2R)],Karnofsky scale(KPS)and the MOS item short from health survey(SF-36)score,serum albumin level,white blood cell count,neutrophil count,platelet count,incidence of toxic and side effects and clinical efficacy were compared between the two groups.Results Compared with before treatment,after treatment,the KPS score,SF-36 score,TNF-α,serum albumin level,white blood cell count,neutrophil count,and platelet count of the two groups increased(P<0.05),and the treatment group were higher than the control group(P<0.05);the level of sIL-2R decreased(P<0.05),and the treatment group was lower than the control group(P<0.05).The incidence of side effects in the treatment group was 31.67%,and the incidence of side effects in the control group was 73.33%,in the treatment group was lower than the control group(P<0.05);the total effective rate of the treatment group(76.67%)was higher than that of the control group(50.00%)(P<0.05).Conclusion Ginseng Yangrong Decoction for patients with bone marrow suppression after chemotherapy for small cell lung cancer can improve the immune function and clinical symptoms of the patients,improve the quality of life,reduce the incidence of toxic and side effects,and enhance the efficacy.

关 键 词：人参养荣汤 小细胞肺癌 化疗 骨髓抑制 白蛋白 

分 类 号：R734.2[医药卫生—肿瘤]