肿瘤患者个体化治疗药物筛选技术研究进展  

RESEARCH PROGRESS IN INDIVIDUALIZED DRUG SCREENING TECHNOLOGY FOR PATIENTS WITH TUMORS

作　　者：伍晓晓 刘美佑 彭莉 程梁华 王番 王婧雯 贾艳艳 WU Xiao-xiao;LIU Meiyou;PENG Li;CHENG Lianghua;WANG Fan;WANG Jingwen;JIA Yanyan(Department of Pharmacy,First Affiliated Hospital of Air Force Military Medical University of Chinese People’s Liberation Army,Xi′an 710000,China)

机构地区：[1]中国人民解放军空军军医大学第一附属医院药剂科,陕西西安710000

出　　处：《精准医学杂志》2023年第6期556-559,共4页Journal of Precision Medicine

基　　金：西安市科技计划项目[20YXYJ0009(4)]

摘　　要：目前,我国肿瘤发病率逐年攀升,每年新发肿瘤患者数目已居世界首位。现今肿瘤常规治疗方法为手术联合放化疗、靶向治疗和免疫治疗,但不同肿瘤患者对化疗药物敏感性存在巨大差异,故通过体外药物敏感性筛选技术筛选患者最为敏感的药物,从而指导患者个体化用药尤为重要。目前肿瘤患者个体化用药筛选技术较多,每项技术各有优缺点,本文对常用的几种技术的应用进行综述,为肿瘤患者个体化用药技术的筛选提供参考。In China,the incidence of tumors is increasing year by year,with the number of patients with new tumors ranking first in the world.Currently,tumors are usually treated with surgery combined with radiotherapy,chemotherapy,targeted therapy,or immunotherapy.However,individuals with tumors vary substantially in response to chemotherapeutic drugs.Therefore,selecting the drugs that patients are most sensitive to through the in vitro drug sensitivity screening technology is of great importance to guide personalized drug treatment of patients with tumors.Currently,there are various techniques for personalized anti-tumor drug screening,each with its own advantages and disadvantages.This article reviews the application progress on several commonly used techniques,with the aim to provide a reference for the selection of personalized anti-tumor drug screening techno-logy.

关 键 词：肿瘤 药物筛选试验 抗肿瘤 基因组测序 类器官 异种移植模型抗肿瘤试验 精准医学 疾病模型 动物 综述 

分 类 号：R730.5[医药卫生—肿瘤] R965.1[医药卫生—临床医学]