免疫性肠内营养支持对食管癌放疗患者的效果观察  

Effect of immunological enteral nutrition support on esophageal cancer patients treated with radiotherapy

作　　者：王霞[1] 贺丽亚[1] 刘苗苗[1] 范静[1] 蒋彩霞[1] WANG Xia;HE Liya;LIU Miaomiao(Hebei General Hospital,Hebei,Shijiazhuang 050071,China)

机构地区：[1]河北省人民医院,石家庄市050071

出　　处：《河北医药》2023年第23期3577-3580,共4页Hebei Medical Journal

基　　金：河北省卫生健康委员会科学研究课题项目(编号:20190270)。

摘　　要：目的探究免疫性肠内营养支持治疗对改善食管癌放疗患者治疗效果的意义。方法收集2019年2月至2020年10月就诊于河北省人民医院且经病理科诊断为鳞状细胞癌的食管鳞癌患者共100例,随机分为试验组(免疫性肠内营养联合放疗)和对照组(单纯放疗),每组50例。通过比较2组患者的临床疗效、毒性反应、免疫因子的表达、营养指标的水平及生活质量,进而评估免疫性肠内营养支持治疗对食管癌患者的治疗效果。结果试验组患者临床疗效的总体有效率显著高于对照组(P<0.05);试验组患者毒性反应的比例明显低于对照组(P<0.05);治疗后,试验组患者体内CD_(3)^(+)、CD_(4)^(+)的比例较治疗前及对照组治疗后均明显升高(P<0.05),而试验组CD_(4)^(+)/CD_(8)^(+)的比例较治疗前及对照组治疗后均明显升高(P<0.05);治疗后,试验组患者营养指标的水平较对照组明显升高(P<0.05);但治疗前2组患者营养指标的水平无明显变化(P>0.05);治疗后,试验组患者的生活质量明显优于对照组(P<0.05);但治疗前2组患者生活质量无明显变化(P>0.05)。结论免疫性肠内营养支持治疗可有效降低食管癌放疗患者毒性反应,改善体内免疫因子的表达水平,提高免疫力及生活质量,最终可有效改善临床症状,对食管癌放疗患者具有一定的治疗意义。Objective To explore the significance of immunological enteral nutrition support in improving the therapeutic effect of radiotherapy in esophageal cancer(EC)patients.Methods A total of 100 patients who were admitted to Hebei General Hospital and diagnosed as esophageal squamous cell carcinoma by the Pathology Department from February 2019 to October 2020 were recruited.They were randomly divided into experimental group(immunological enteral nutrition combined with radiotherapy,n=50)and control group(radiotherapy alone,n=50).The clinical efficacy,toxicity,expression levels of immune factors,nutritional indicators and quality of life were compared between groups,thus evaluating the therapeutic effect of immunological enteral nutrition support on EC patients.Results The overall effective rate of the experimental group was significantly higher than that of the control group(P<0.05).The proportion of toxic reaction in the experimental group was significantly lower than that of the control group(P<0.05).After treatment,the proportions of patients with CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were significantly higher in the experimental group than those of control group,which were also significantly higher than that before treatment(P<0.05).Nutritional index levels and the quality of life were comparable before treatment between groups(P>0.05),which were significantly higher in the experimental group after treatment than those of control group(P<0.05).Conclusion Immunological enteral nutrition support can effectively reduce the occurrence of toxic reactions in esophageal cancer patients treated with radiotherapy,which upregulate immune factors,improve the immunity and quality of life,and ultimately alleviate the clinical symptoms.It offers a certain therapeutic significance for esophageal cancer patients treated with radiotherapy.

关 键 词：免疫性肠内营养支持治疗 食管鳞癌 放疗 生活质量 

分 类 号：R735.1[医药卫生—肿瘤]