Effect of Shan Zha(Hawthorn or Crataegus)on gastrointestinal cancer:A network pharmacology and molecular docking study  

作　　者：Jing Yang Jialin Gu Ying Shen Ling Cao Hong Zhou Wei Zhu 

机构地区：[1]Oncology Center,The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University,Wujiang,Jiangsu 215228,China [2]Department of Traditional Chinese Medicine,The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University,Wujiang,Jiangsu 215228,China [3]Department of Endocrinology,The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University,Wujiang,Jiangsu 215228,China [4]Department of Oncology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Cancer Pathogenesis and Therapy》2023年第4期229-237,共9页癌症发生与治疗（英文）

基　　金：This study was financially supported by the National Mentoring System Project for Young Health Talents in Suzhou(No.201948).

摘　　要：Background Shan Zha(Hawthorn or Crataegus)is a traditional Chinese medicine(TCM)most commonly used for the treatment of hyperlipidemia.Gastrointestinal cancer is closely correlated with blood lipid levels.This study illustrates the potential anticancer effects of Shan Zha on gastrointestinal tumors based on network pharmacology and molecular docking.Methods Hawthorn's bioactive ingredients and drug targets were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine version 2.0(TCMIP v2.0),and Herbal Ingredients'Targets Platform(HIT 2.0)databases.Validated disease targets of gastrointestinal cancer were obtained from the Therapeutic Targets Database(TTD)and HIT 2.0 databases.Protein–protein interaction analysis of intersecting genes was performed using the Search Tool for the Retrieval of Interacting Genes(STRING)database.The functions of these genes were further analyzed by performing gene ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses.Molecular docking verification was performed using Molecular Operating Environment(MOE)software.Results Four main bioactive components were identified in Shan Zha.A total of 271 potential drug targets were identified,and 393 gastrointestinal-tumor targets were obtained.Through protein interaction analysis of intersecting targets,the main components of Shan Zha were found to interact more closely with proteins such as tumor protein p53(TP53),AKT serine/threonine kinase 1(AKT1),JUN proto-oncogene(JUN),interleukin 6(IL6),epidermal growth factor receptor(EGFR),and vascular endothelial growth factor A(VEGFA).KEGG pathway enrichment analysis showed a total of 127 pathways,mainly involving pathways in multiple types of cancer,the Phosphatidylinositol 3-kinase-Akt(PI3K-Akt)signaling pathway,and EGFR tyrosine kinase inhibitor resistance.Combined with The Cancer Genome Atlas(TCGA)differential analysis,key targets,including TP53,c

关 键 词：CRATAEGUS Gastrointestinal cancer HAWTHORN Molecular docking Network pharmacology Shan Zha Traditional Chinese medicine 

分 类 号：R285[医药卫生—中药学]