Multi-disciplinary surgery for simultaneous resection of multiple tumors in a patient with newly diagnosed metastatic pheochromocytoma/paraganglioma  

作　　者：Jibo Jing Lingfeng Meng Yaoguang Zhang Runhua Tang Haoran Wang Jiaxing Ning Xinhao Wang 

机构地区：[1]Department of Urology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100005,China

出　　处：《Cancer Pathogenesis and Therapy》2023年第4期290-294,共5页癌症发生与治疗（英文）

基　　金：This study was supported by the National Key Research and Development Program of China(No.2018YFC2002202);the National High-Level Hospital Clinical Research Funding(No.BJ-2021-184).

摘　　要：Metastatic pheochromocytoma/paraganglioma(MPP)is a rare endocrine tumor that originates from extra-adrenal chromaffin cells such as the paraganglia cells of sympathetic and parasympathetic nerves.It usually causes multiple solid tumors and exhibits strong aggressiveness with poor prognosis,with a reported 5-year survival rate of less than 50%.Cases of brain and retroperitoneal metastases at the initial diagnosis have not yet been reported.We report a 41-year-old male patient initially diagnosed with MPP in the brain and retroperitoneum who underwent multi-disciplinary collaborative surgery and simultaneous removal of two tumors at our center.Postoperative pathology revealed infiltrative growth of a skull base tumor.The patient chose to receive the tyrosine kinase inhibitor sunitinib as a targeted treatment.A 3-month follow-up after surgery showed that the patient recovered well without signs of metastasis or recurrence.We present multi-disciplinary surgery under similar circumstances for enhanced treatment and postoperative management.The patient demonstrates a favorable prognosis during postoperative follow-up,indicating that simultaneous multidisciplinary surgery may offer greater benefits for MPP patients.

关 键 词：Metastatic pheochromocytoma/paraganglioma Multi-disciplinary surgery Skull base tumor Retroperitoneal metastases 

分 类 号：R733.3[医药卫生—肿瘤]