脑瘫伴癫痫患儿脑电放电模式的特征及危险因素  

Characteristics and risk factors of EEG discharge mode patterns in children with cerebral palsy

作　　者：刘学锋 何莉莉 陆彦婷 郑明平 钱丰 LIU Xuefeng;HE Lili;LU Yanting;ZHENG Mingping;QIAN Feng(Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,China)

机构地区：[1]宁德师范学院附属宁德市医院,福建宁德352100

出　　处：《中国实用神经疾病杂志》2023年第12期1506-1511,共6页Chinese Journal of Practical Nervous Diseases

基　　金：福建省临床重点专科建设项目资金支撑(编号:闽卫医政函[2022]884号)。

摘　　要：目的分析脑瘫伴癫痫患儿脑电放电模式的特征及危险因素。方法选取2018-01—2022-01宁德市医院收治的36例脑瘫患儿为研究对象,根据是否伴发癫痫分为脑瘫伴癫痫组(16例)和脑瘫不伴癫痫组(20例),分析脑瘫伴癫痫患儿脑电放电模式的特征及危险因素。结果脑瘫伴癫痫组脑电异常放电发生率93.75%,明显高于脑瘫不伴癫痫组的30.00%,差异有统计学意义(P<0.05)。16例脑瘫伴癫痫患儿的脑电表现为局灶性放电6例(37.50%),多灶性放电3例(18.75%),高峰失律5例(31.25%),广泛性放电1例(6.25%)。单因素分析显示,脑瘫伴癫痫组母体多胎妊娠、新生儿围生期窒息、宫内窘迫、先天畸形、痉挛四肢型脑瘫的发生率均高于脑瘫不伴癫痫组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,母体多胎妊娠、新生儿围生期窒息、宫内窘迫、先天畸形、痉挛四肢型脑瘫是脑瘫伴癫痫的独立危险因素,差异有统计学意义(P<0.05)。结论脑瘫伴癫痫患儿的脑电放电模式以局灶性放电和高峰失律为主,主要危险因素包括母体多胎妊娠、新生儿围生期窒息、宫内窘迫、先天畸形、痉挛四肢型脑瘫,临床应加以重视,并给予积极干预。Objective To explore the characteristics of EEG discharge mode patterns and risk factors for seizures in children with cerebral palsy.Methods From January 2018 to January 2022,36 children with cerebral palsy admitted to Ningde Municipal Hospital were selected as the research subjects.According to whether they had epilepsy,they were divided into cerebral palsy with epilepsy group(n=16)and cerebral palsy without epilepsy group(n=20),and the characteristics and risk factors for brain discharge patterns were analyzed.Results The incidence of abnormal EEG discharge in the cerebral palsy with epilepsy group was 93.75%,and was significantly higher than 30.00%in the cerebral palsy without epilepsy group,with a statistically significant difference(P<0.05).The EEG findings in 16 children of cerebral palsy with epilepsy were 6(37.50%)cases of focal discharges,3(18.75%)cases of multifocal discharges,5(31.25%)cases of hyperdisturbed,and 1(6.25%)case of generalized discharge.The results of univariate analysis showed that the incidence of maternal multiple pregnancy,perinatal asphyxia,intrauterine distress,congenital malformation,and spasm in the cerebral palsy with epilepsy group was higher than that of cerebral palsy without epilepsy group,and the difference was statistically significant(P<0.05).The results of multivariate Logistic regression analysis showed that maternal multiple pregnancy,perinatal asphyxia,intrauterine distress,congenital malformation,and spspasm were independent risk factors for cerebral palsy with epilepsy,with statistically significant differences(P<0.05).Conclusion The EEG discharge mode of epilepsy in children with cerebral palsy is mainly focal discharge and high arrhythmia.The main risk factors include maternal multiple pregnancy,neonatal perinatal asphyxia,intrauterine distress,congenital malformation,spasm and limb cerebral palsy,which should be paid attention to clinically and given active intervention measures.

关 键 词：脑瘫 癫痫 脑电放电模式 特征 危险因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]