乳腺癌患者426例临床特征及危险因素分析  

Clinical features and risk factors of 426 patients with breast cancer

作　　者：宿娜[1] 山周琦玥 辛毅[2] SU Na;SHANZHOU Qiyue;XIN Yi(Department of Oncology and Hematology,Chongzhou People’s Hospital,Chongzhou 611230,China)

机构地区：[1]崇州市人民医院肿瘤血液科,四川崇州611230 [2]崇州市人民医院甲乳外科,四川崇州611230

出　　处：《陕西医学杂志》2023年第12期1707-1710,共4页Shaanxi Medical Journal

基　　金：四川省医学青年创新科研课题(Q22080)。

摘　　要：目的:分析乳腺癌患者临床特征及发病危险因素。方法:选取乳腺癌426例为乳腺癌组,按1∶1比例纳入同期体检健康的女性426例为对照组。统计乳腺癌患者人口社会学特征,采用条件Logistic回归分析乳腺癌发病的危险因素。结果:426例乳腺癌患者中,发病年龄集中在41~50岁(43.90%),肿瘤多位于乳腺外上(51.41%),病理诊断多为浸润性导管癌(55.16%),其淋巴转移率也最高(65.53%),临床病理分期集中在Ⅱ期(73.24%),患者主要选择改良根治术治疗(81.69%)。经单因素分析发现,乳腺癌组与对照组年龄、职业、体重指数(BMI)、受教育水平、家庭年收入、婚姻状态、初潮时间、乳腺癌家族史、乳腺癌良性疾病史、生育史及哺乳史比较差异有统计学意义(均P<0.05),两组居住地、月经状态比较差异无统计学意义(均P>0.05)。条件Logistic回归分析提示,BMI≥30 kg/m^(2)、初潮时间<12岁、乳腺癌家族史、乳腺癌良性疾病史是乳腺癌发病的危险因素,而哺乳史是乳腺癌发生的保护因素(均P<0.05)。结论:乳腺癌多发于41~50岁妇女,肿瘤多位于乳腺外上部,浸润性导管癌占比最高,目前改良根治术是乳腺癌主要治疗方式。BMI≥30 kg/m^(2)、初潮时间<12岁及存在乳腺癌家族史、乳腺良性疾病史均是乳腺癌发病的危险因素,而哺乳史是乳腺癌发生的保护因素。Objective:To investigate the clinical features and risk factors of 426 patients with breast cancer.Methods:A total of 426 women with breast cancer were enrolled as the breast cancer group,and 426 healthy women were enrolled as the control group at a ratio of 1∶1.The demographic and sociological characteristics of breast cancer patients were analyzed,and the risk factors of breast cancer were analyzed by conditional Logistic regression.Results:Among the 426 patients with breast cancer,the age of onset was concentrated between 41 and 50 years old(43.90%),the tumors were mostly located in the outer upper breast(51.41%),the pathological diagnosis was mostly invasive ductal carcinoma(55.16%)and the lymph node metastasis rate was the highest(65.53%),and the clinical pathological stage was concentrated in stageⅡ(73.24%),and most patients chose modified radical surgery(81.69%).Single factor analysis found that the age,occupation,BMI,education level,family income,marital status,menstruation,family history of breast cancer,breast cancer,benign disease history,family history,and lactation history in breast cancer group were statistically different from control group(all P<0.05),and there were no significant differences in residence and menstrual status between the two groups(all P>0.05).Conditional Logistic regression analysis showed that BMI≥30 kg/m^(2),menarche time<12 years old,family history of breast cancer,and history of benign breast cancer were risk factors for breast cancer,while breast-feeding history was a protective factor for breast cancer(all P<0.05).Conclusion:Breast cancer mostly occurs in women aged 41 to 50 years old,and the tumors are mostly located in the outer upper breast,with invasive ductal carcinoma accounting for the highest proportion.Modified radical mastectomy is the main treatment for breast cancer at present.BMI≥30 kg/m^(2),menarche time<12 years old,family history of breast cancer and history of benign breast diseases are risk factors for breast cancer,while breast-feeding history is

关 键 词：乳腺癌 临床特征 危险因素 预防 保护因素 

分 类 号：R737.9[医药卫生—肿瘤]