女贞莲桂白芍汤联合常规辅助化疗治疗三阴性乳腺癌术后疗效研究  

Effects of Nvzhen Liangui Baishao decoction combined with routine adjuvant chemotherapy in the treatment of patients with triple negative breast cancer after surgery

作　　者：王成 王晓玲[1] 汪旻琦[1] 何宁一 洪月光[1] WANG Cheng;WANG Xiaoling;WANG Minqi;HE Ningyi;HONG Yueguang(Department of Oncology,Qinhuangdao Hospital of Traditional Chinese Medicine,Qinhuangdao 066003,China)

机构地区：[1]秦皇岛市中医医院肿瘤科,河北秦皇岛066003

出　　处：《陕西中医》2023年第12期1735-1739,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研课题(2020369)。

摘　　要：目的:观察女贞莲桂白芍汤联合常规辅助化疗对三阴性乳腺癌术后患者疗效及免疫功能、血清肿瘤标志物水平的影响。方法:选取行手术治疗的78例三阴性乳腺癌患者为研究对象,采用随机数字表法分为两组。化疗组(n=39)给予常规化疗治疗,中药组(n=39)给予女贞莲桂白芍汤联合常规化疗治疗。统计两组疗效,检测两组免疫功能指标、肿瘤标志物、血管内皮生长因子(VEGF)的水平,评估两组中医症状评分的差异,记录两组不良反应。结果:中药组总有效率高于化疗组,差异有统计学意义(P<0.05)。治疗前两组免疫功能指标、肿瘤标志物、VEGF、中医症状积分水平比较,差异无统计学意义(均P>0.05)。治疗后,中药组CD3^(+)绝对计数、CD4^(+)绝对计数、NK细胞、CD4^(+)/CD8^(+)高于化疗组,CD8^(+)绝对计数低于化疗组(均P<0.05)。中药组治疗后肿瘤标志物、血管内皮生长因子A(VEGFA)、血管内皮生长因子C(VEGFC)水平低于化疗组,差异有统计学意义(均P<0.05)。与治疗前比较,两组治疗后头晕目眩、耳鸣、五心烦热、失眠多梦、健忘、口燥咽干、颧红盗汗、腰膝酸软、胁肋胀痛等评分下降,且中药组低于化疗组(均P<0.05)。中药组胃肠道反应、骨髓抑制Ⅲ-Ⅳ级发生率低于化疗组(均P<0.05);中药组皮疹、脱发、神经毒性、心脏毒性Ⅲ-Ⅳ级发生率与化疗组比较,差异无统计学意义(均P>0.05)。结论:女贞莲桂白芍汤联合常规辅助化疗治疗可降低三阴性乳腺癌术后患者肿瘤标志物的表达,调节免疫功能,减少不良反应。Objective:To observe the effects of Nvzhen Liangui Baishao decoction combined with routine adjuvant chemotherapy on the efficacy,immune function and serum tumor markers of patients with triple negative breast cancer after surgery.Methods:78 patients with triple negative breast cancer who underwent surgical treatment were selected and divided into two groups by random number table method.Chemotherapy group(n=39)was treated with conventional chemotherapy,and Chinese medicine group(n=39)was treated with Nvzhen Liangui Baishao decoction combined with conventional chemotherapy.The therapeutic effects of the two groups were evaluated,the levels of immune function indexes,tumor markers and vascular endothelial growth factor family(VEGF)of the two groups were detected.The differences in TCM symptom scores between the two groups were evaluated.Two groups of toxic and side effects were recorded.Results:The total effective rate of decoction group was higher than that of chemotherapy group,the difference was statistically significant(P<0.05).There was no significant difference in immune function indexes,tumor markers,VEGF and TCM symptom scores between the two groups before treatment(all P>0.05).After treatment,the absolute count of CD3+,CD4+,NK cells and CD4+/CD8+in Chinese medicine group were higher than those in chemotherapy group,and the absolute count of CD8+was lower than those in chemotherapy group(all P<0.05).After treatment,the levels of tumor markers,VEGFA and VEGFC in TCM group were lower than those in chemotherapy group,and the differences were statistically significant(all P<0.05).Compared with before treatment,the scores of dizziness,tinnitus,five upset fever,insomnia and dreams,forgetfulness,dry mouth and throat,zygomatic red night sweat,waist and knee pain,hypochetal swelling and pain were decreased in the two groups after treatment,and the Chinese medicine group was lower than the chemotherapy group(all P<0.05).The incidence of gastrointestinal reaction and myelosuppression of gradeⅢtoⅣin Chinese medicin

关 键 词：三阴性乳腺癌 女贞莲桂白芍汤 化疗 增效减毒 免疫功能 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]