奥沙利铂联合氟尿嘧啶治疗老年晚期胃癌患者的临床疗效及不良反应  

Clinical efficacy and adverse reaction of oxaliplatin combined with fluorouracil in the treatment of elderly patients with advanced gastric cancer

作　　者：杨琼 刘万宝 白娟 刘迎宾 邹婕 YANG Qiong;LIU Wanbao;BAI Juan;LIU Yingbin;ZOU Jie(Department of Pharmacy,Xi’an International Medical Center Hospital,Xi’an 710100,Shaanxi,China;Department of Pharmacy,Xijing Hospital,Air Force Military Medical University,Xi’an 710032,Shaanxi,China;Department of Oncology,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,Shaanxi,China)

机构地区：[1]西安国际医学中心医院药学部,西安710100 [2]空军军医大学西京医院药剂科,西安710032 [3]西安交通大学第二附属医院肿瘤科,西安710004

出　　处：《癌症进展》2023年第19期2121-2123,2143,共4页Oncology Progress

基　　金：陕西省重点研发计划项目(2019ZD-SF-055)。

摘　　要：目的探讨奥沙利铂联合氟尿嘧啶治疗老年晚期胃癌患者的临床疗效及不良反应。方法根据治疗方式的不同将120例老年晚期胃癌患者分为对照组(n=60,伊立替康联合氟尿嘧啶治疗)和观察组(n=60,奥沙利铂联合氟尿嘧啶治疗)。比较两组患者的临床疗效、疾病进展时间、不良反应发生情况及生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]。结果两组患者的客观缓解率、疾病控制率及疾病进展时间比较,差异均无统计学意义(P﹥0.05)。观察组患者白细胞减少、腹泻及周围神经病变发生率均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者EORTC QLQ-C30各维度评分均高于本组治疗前,观察组患者认知功能、角色功能、社会功能评分均高于对照组,差异均有统计学意义(P﹤0.05)。结论奥沙利铂联合氟尿嘧啶治疗老年晚期胃癌患者能够获得与伊立替康联合氟尿嘧啶较为相似的临床疗效,但前者的安全性更高,且可提高患者的生活质量,值得临床推广。Objective To investigate the clinical efficacy and adverse reaction of oxaliplatin combined with fluorouracil in the treatment of elderly patients with advanced gastric cancer.Method A total of 120 elderly patients with advanced gastric cancer were divided into control group(n=60,treated with irinotecan combined with fluorouracil)and observation group(n=60,treated with oxaliplatin combined with fluorouracil)according to different treatment methods.The clinical efficacy,disease progression time,adverse reaction,and quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)]were compared between the two groups.Result There were no significant differences in the objective response rate,disease control rate and disease progression time between the two groups(P>0.05).The incidence rates of leukopenia,diarrhea and peripheral neuropathy in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of each dimension of EORTC QLQ-C30 in the two groups were higher than those before the treatment,the cognitive function,role function,and social function scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Oxaliplatin combined with fluorouracil could achieve comparable clinical efficacy to that of irinotecan plus fluorouracil in the treatment of elderly patients with advanced gastric cancer.However,the former regimen is worthy of clinical promotion owing to its high safety and improvement of patients’quality of life.

关 键 词：晚期胃癌 奥沙利铂 氟尿嘧啶 临床疗效 不良反应 

分 类 号：R735.2[医药卫生—肿瘤]