血清胃泌素释放肽前体、神经元特异性烯醇化酶单独及联合检测对小细胞肺癌的诊断价值及与患者临床特征的关系  

Diagnostic value of serum pro-gastrin-releasing peptide and neuron specific enolase alone and in combination for small cell lung cancer and their relationship with clinical characteristics of patients

作　　者：韩金利[1] 杨冉[2] 朱卫伟[1] 彭慧斌 魏昕 张楠[1] 李红敏[1] 王洁 徐帅华 HAN Jinli;YANG Ran;ZHU Weiwei;PENG Huibin;WEI Xin;ZHANG Nan;LI Hongmin;WANG Jie;XU Shuaihua(Medical Laboratory,Anyang Tumor Hospital,Anyang 455003,He’nan,China;Department of Thoracic Surgery,Anyang Tumor Hospital,Anyang 455003,He’nan,China)

机构地区：[1]安阳市肿瘤医院医学检验科,河南安阳455003 [2]安阳市肿瘤医院胸外科,河南安阳455003

出　　处：《癌症进展》2023年第19期2124-2127,共4页Oncology Progress

基　　金：2021年河南省医学科技攻关计划联合共建项目(LHGJ20210879)。

摘　　要：目的探讨血清胃泌素释放肽前体(ProGRP)、神经元特异性烯醇化酶(NSE)单独及联合检测对小细胞肺癌(SCLC)的诊断价值及与患者临床特征的关系。方法选取257例肺部疾病患者,检测患者血清ProGRP和NSE水平,以SCLC为阳性,肺良性病变和非小细胞肺癌(NSCLC)为阴性,评估ProGRP、NSE单独及联合检测对SCLC的诊断价值,比较不同临床特征SCLC患者血清ProGRP、NSE的阳性表达情况。结果病理检查结果显示,SCLC患者40例,NSCLC患者155例,肺良性病变患者62例。SCLC患者血清ProGRP、NSE水平均高于NSCLC和肺良性病变患者,差异均有统计学意义(P﹤0.05)。ProGRP+NSE检测诊断SCLC的灵敏度高于NSE单独检测,差异有统计学意义(P﹤0.05);ProGRP+NSE检测与ProGRP单独检测诊断SCLC的灵敏度比较,差异无统计学意义(P﹥0.05);ProGRP单独检测诊断SCLC的特异度和准确度均高于ProGRP+NSE检测和NSE单独检测,差异均有统计学意义(P﹤0.05)。广泛期、肿瘤大小﹥3 cm、远处转移SCLC患者血清ProGRP、NSE阳性表达率均高于局限期、肿瘤大小≤3 cm、无远处转移患者,差异均有统计学意义(P﹤0.05)。结论ProGRP单独检测诊断SCLC的灵敏度与ProGRP+NSE联合检测相比无明显差异,高于NSE单独检测,且ProGRP单独检测的诊断准确度最高。血清ProGRP、NSE水平与SCLC患者临床分期、肿瘤大小及远处转移情况有关,对SCLC的诊断及病情评估有重要意义。Objective To explore the diagnostic value of serum pro-gastrin-releasing peptide(ProGRP)and neuron specific enolase(NSE)alone and in combination for small cell lung cancer(SCLC)and their relationship with clinical characteristics of patients.Method A total of 257 patients with lung diseases were selected,and to measure their serum ProGRP and NSE levels.The diagnostic value of ProGRP and NSE alone and in combination for SCLC was evaluated,with SCLC being positive,lung benign lesions and non-small cell lung cancer(NSCLC)being negative and the positive expression of ProGRP and NSE in serum of SCLC patients with different clinical characteristics of were compared.Result The pathological examination result showed that there were 40 SCLC patients,155 NSCLC patients,and 62 patients with benign lung lesions.The serum ProGRP and NSE in SCLC patients were significantly higher than those with NSCLC and benign lung lesions(P<0.05).The sensitivity of ProGRP+NSE in the diagnosis of SCLC was higher than that NSE detection alone(P<0.05).There was no significant difference for the sensitivity of ProGRP+NSE and ProGRP alone in the diagnosis of SCLC(P>0.05).The specificity and accuracy of the diagnosis of SCLC by ProGRP detection alone was higher than ProGRP+NSE detection and NSE detection alone(P<0.05).The positive expression rates of ProGRP and NSE in serum of patients with extensive stage,tumor size>3 cm,and distant metastasis SCLC were higher than those with limited stage,tumor size≤3 cm,and no distant metastasis,the differences were statistically significant(P<0.05).Conclusion The sensitivity of ProGRP alone in diagnosing SCLC is not significantly different from ProGRP+NSE combined detection,and is higher than that of NSE alone detection.Moreover,ProGRP alone has the highest diagnostic accuracy.The levels of serum ProGRP and NSE are related to the staging,tumor size,and distant metastasis of SCLC patients,which are of great significance for the diagnosis and disease evaluation of SCLC.

关 键 词：小细胞肺癌 胃泌素释放肽前体 神经元特异性烯醇化酶 

分 类 号：R734.2[医药卫生—肿瘤]