高危型人乳头瘤病毒多重感染与宫颈癌患者临床特征的关系  

Relationship between multiple infection of high-risk human papilloma virus and clinical characteristics of patients with cervical cancer

作　　者：杨然[1] 董莉丽 汪爱兵[1] 冯磊[1] 张清伟 YANG Ran;DONG Lili;WANG Aibing;FENG Lei;ZHANG Qingwei(Department of Gynecology,Nanyang Central Hospital,Nanyang 473009,He’nan,China;Department of Gynecology,the First People’s Hospital of Luohe,Luohe 462000,He’nan,China)

机构地区：[1]南阳市中心医院妇科,河南南阳473009 [2]漯河市第一人民医院妇科,河南漯河462000

出　　处：《癌症进展》2023年第19期2136-2139,共4页Oncology Progress

基　　金：漯河医学高等专科学校创新创业发展能力提升工程项目(2019-LYZKYZD017)。

摘　　要：目的探讨高危型人乳头瘤病毒(HR-HPV)多重感染与宫颈癌患者临床特征的关系。方法根据HR-HPV感染情况的不同将158例HR-HPV阳性宫颈癌患者分为单一感染组(n=119)和多重感染组(n=39)。记录两组患者的HR-HPV亚型分布情况,比较两组患者的临床特征,采用Logistic回归模型分析宫颈癌患者合并HR-HPV多重感染的影响因素。比较HR-HPV二重感染、三重感染、四重感染宫颈癌患者的临床特征。结果单一感染组HR-HPV亚型以16型(94.96%)、18型(2.52%)居多;多重感染组以二重感染(82.05%)为主,三重感染(12.82%)、四重感染(5.13%)较少,其中二重感染HR-HPV亚型以16+18型(38.46%)、16+33型(12.82%)、16+59型(10.26%)居多。多重感染组中年龄≥65岁、低分化、有淋巴结转移的患者比例均高于单一感染组,差异均有统计学意义(P﹤0.05)。年龄≥65岁、低分化、淋巴结转移均是宫颈癌患者合并HR-HPV多重感染的独立危险因素(P﹤0.05)。HR-HPV二重感染、三重感染、四重感染宫颈癌患者的年龄、病理类型、临床分期、分化程度、淋巴结转移情况比较,差异均无统计学意义(P﹥0.05)。结论宫颈癌患者HR-HPV多重感染与年龄较高、低分化、淋巴结转移有关,HR-HPV多重感染可能参与宫颈癌进展,及时治疗HR-HPV多重感染有利于宫颈癌防控。Objective To investigate the relationship between multiple infection of high-risk human papilloma virus(HR-HPV)and clinical characteristics of cervical cancer patients.Method A total of 158 HR-HPV positive cervical cancer patients were divided into single infection group(n=119)and multiple infection group(n=39)according to different HR-HPV infection status.The distribution of HR-HPV subtypes in the two groups were recorded.The clinical characteristics of the two groups were compared.Logistic regression model was used to analyze the influencing factors for HR-HPV multiple infection in cervical cancer patients.The clinical characteristics of cervical cancer patients with HR-HPV double infection,triple infection,and quadruple infection were also compared.Result The majority of HR-HPV subtypes in the single infection group were type 16(94.96%)and type 18(2.52%).Double infection was(82.05%)dominant,while triple infection(12.82%)and quadruple infection(5.13%)were less common in the multiple infection group.Among them,the most common HR-HPV subtypes for double infection were type 16+18(38.46%),type 16+33(12.82%),and type 16+59(10.26%).The proportion of patients aged≥65 years,poorly differentiated,and with lymph node metastasis in the multiple infection group were higher than those in the single infection group,and the differences were statistically significant(P<0.05).Age≥65 years,poor differentiation,and lymph node metastasis were independent risk factors for HR-HPV multiple infection in cervical cancer patients(P<0.05).There were no significant differences in the age,pathological type,clinical stage,degree of differentiation,and lymph node metastasis of cervical cancer patients with HR-HPV double fection,triple infection,and quadruple infection(P>0.05).Conclusion HR-HPV multiple infection in cervical cancer patients are related to older age,poor differentiation,and lymph node metastasis.HR-HPV multiple infection may be involved in the progression of cervical cancer.Timely treatment of HR-HPV multiple infection is

关 键 词：宫颈癌 高危型人乳头瘤病毒 多重感染 临床特征 

分 类 号：R737.33[医药卫生—肿瘤]