MTHFR(C677T)基因多态性和同型半胱氨酸与急性脑梗死患者静脉血栓形成的相关性研究  

Correlation between MTHFR(C677T)gene polymorphism,homocysteine and venous thrombosis in patients with acute cerebral infarction

作　　者：潘秀锋 李付广[1] 李敏婷 吴爱娟 PAN Xiufeng;LI Fuguang;LI Minting;WU Aijuan(Molecular Diagnostic Center,the Sixth Affiliated Hospital of Guangzhou Medical University/Qingyuan People's Hospital,Qingyuan,Guangdong 511518,China)

机构地区：[1]广州医科大学附属第六医院/清远市人民医院分子诊断中心,广东清远511518

出　　处：《检验医学与临床》2023年第23期3480-3484,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨MTHFR(C677T)基因多态性和同型半胱氨酸(Hcy)与急性脑梗死患者静脉血栓形成的相关性。方法回顾性分析2020年11月至2021年10月该院收治的334例急性脑梗死患者作为脑梗死组,另选取同期在该院体检中心就诊的100例健康体检者作为健康组。脑梗死组患者根据是否发生静脉血栓分为血栓组(80例)和非血栓组(254例)。检测所有研究对象MTHFR(C677T)基因型及Hcy水平,比较脑梗死组和健康组的MTHFR(C677T)基因型和等位基因频率,比较血栓组和非血栓组的MTHFR(C677T)基因型和基因频率、临床资料、携带不同MTHFR(C677T)基因型患者的Hcy水平。采用二元Logistic回归分析急性脑梗死患者静脉血栓形成的危险因素。结果脑梗死组MTHFR(C677T)基因的TT基因型与T等位基因频率高于健康组,差异均有统计学意义(P<0.05)。血栓组MTHFR(C677T)CT基因型、TT基因型和T等位基因频率高于非血栓组,差异均有统计学意义(P<0.05);血栓组和非血栓组年龄、吸烟情况比较,差异均有统计学意义(P<0.05)。血栓组与非血栓组携带MTHFR(CT77T)基因TT基因型患者的Hcy水平高于CT和CC基因型,且CT基因型高于CC基因型,差异均有统计学意义(P<0.05);二元Logistic回归分析结果显示,携带MTHFR(CT77T)基因TT基因型、Hcy≥15μmol/L是急性脑梗死患者静脉血栓形成的危险因素(P<0.05)。结论MTHFR(C677T)基因多态性会对Hcy水平产生影响,从而引发急性脑梗死患者形成静脉血栓,在临床中应对携带MTHFR(C677T)基因TT基因型的急性脑梗患者给予关注,预防静脉血栓的形成。Objective To investigate the correlation between MTHFR(C677T)gene polymorphism,homocysteine(Hcy)and venous thrombosis in patients with acute cerebral infarction.Methods A total of 334 patients with acute cerebral infarction admitted to this hospital from November 2020 to October 2021 were retrospectively analyzed as the cerebral infarction group,and 100 healthy people who underwent physical examination in the physical examination center during the same period were selected as the healthy group.The patients in the cerebral infarction group were divided into thrombosis group(n=80)and non-thrombosis group(n=254)according to the presence or absence of venous thrombosis.The MTHFR(C677T)genotype and Hcy level were detected in all subjects.The MTHFR(C677T)genotype and allele frequency were compared between the cerebral infarction group and the healthy group,and the MTHFR(C677T)genotype and allele frequency,clinical data and Hcy level were compared between the thrombosis group and the non-thrombosis group.Binary Logistic regression was used to analyze the risk factors of venous thrombosis in patients with acute cerebral infarction.Results The TT genotype and T allele frequency of MTHFR C677T gene in the cerebral infarction group were higher than those in the healthy group,and the differences were statistically significant(P<0.05).The frequencies of MTHFR(C677T)CT genotype,TT genotype and T allele in the thrombosis group were higher than those in the non-thrombosis group,and the differences were statistically significant(P<0.05).There were significant differences in age and smoking between the thrombosis group and the non-thrombosis group(P<0.05).The Hcy level of MTHFR(C677T)gene TT genotype in the thrombosis group and the non-thrombosis group was higher than that of CT and CC genotypes,and CT genotype was higher than CC genotype,the differences were statistically significant(P<0.05).Binary Logistic regression analysis showed that carrying TT genotype of MTHFR(C677T)gene,and Hcy≥15μmol/L were risk factors for venous th

关 键 词：MTHFR(C677T)基因多态性 急性脑梗死 静脉血栓 

分 类 号：R394.3[医药卫生—医学遗传学]