丁苯酞胶囊联合依达拉奉对急性脑梗死患者神经功能及血清VEGF、TMAO、TXA2水平的影响  

Effects of butylphthalide capsule combined with edaravone on neurological function and levels of serum VEGF,TMAO and TXA2 in patients with acute cerebral infarction

作　　者：徐生辉 陈继杰 闻涛 XU Shenghui;CHEN Jijie;WEN Tao(Department of Neurology,Xinyang Third People's Hospital,Xinyang,Henan 464000,China)

机构地区：[1]河南省信阳市第三人民医院神经内科,河南信阳464000

出　　处：《检验医学与临床》2023年第23期3518-3521,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨丁苯酞胶囊联合依达拉奉对急性脑梗死(ACI)患者神经功能及血管内皮生长因子(VEGF)、氧化三甲铵(TMAO)、血栓素A2(TXA2)水平的影响。方法选取2019年12月至2023年2月该院收治的204例ACI患者作为研究对象,按照随机数字表法将其分为对照组和研究组,各102例。研究组给予丁苯酞胶囊联合依达拉奉治疗,对照组给予依达拉奉治疗。比较研究组和对照组临床疗效、脑动脉[大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)]血流流速、血小板功能[血小板P选择素(CD62p)、聚集率、黏附率]指标水平、血清细胞因子[TMAO、VEGF、TXA2、碱性成纤维细胞生长因子(bFGF)]水平。结果治疗后研究组总有效率高于对照组(P<0.05);治疗后研究组和对照组ACA、MCA、PCA血流流速快于治疗前,且研究组快于对照组,差异均有统计学意义(P<0.05);治疗后研究组和对照组血小板CD62p、聚集率、黏附率低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);治疗后研究组和对照组血清TMAO、TXA2水平低于治疗前,且研究组低于对照组,血清VEGF、bFGF水平高于治疗前,且研究组高于对照组,差异均有统计学意义(P<0.05)。结论丁苯酞胶囊联合依达拉奉治疗ACI的效果良好,可改善神经功能、血管内皮细胞及血小板功能,提高脑血流量。Objective To investigate the effect of butylphthalide capsule combined with edaravone on neurological function and levels of serum vascular endothelial growth factor(VEGF),trimethylammonium oxide(TMAO)and thromboxane A2(TXA2)in patients with acute cerebral infarction(ACI).Methods A total of 204 ACI patients admitted to this hospital from December 2019 to February 2023 were selected as the research objects,and they were divided into a control group and a study group by random number table method,with 102 cases in each group.The study group was treated with butylphthalide capsule combined with edaravone,and the control group was treated with edaravone.The clinical efficacy,cerebral artery[anterior cerebral artery(ACA),middle cerebral artery(MCA),posterior cerebral artery(PCA)]flow velocity,platelet function[platelet P-selectin(CD62p),aggregation rate,adhesion rate]indicators levels,serum cytokines[TMAO,VEGF,TXA2,basic fibroblast growth factor(bFGF)]levels before and after treatment were compared between the study group and control group.Results After treatment,the total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the blood flow velocities of ACA,MCA and PCA of the study group and control group were faster than those before treatment,and those in the study group were faster than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the platelet CD62p,aggregation rate and adhesion rate of the study group and control group were lower than those before treatment,and those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum TMAO and TXA2 in the study group and control group were lower than those before treatment,and those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum VEGF and bFGF in the study group and co

关 键 词：神经功能 急性脑梗死 丁苯酞胶囊 依达拉奉 

分 类 号：R743.32[医药卫生—神经病学与精神病学]