具有休眠特征的播散肿瘤细胞体内外研究模型的建立及应用  

Establishment and Application of in vitro and in vivo Model of Disseminated Tumor Cells with Dormancy

作　　者：阙祖俊 刘佳君 田建辉[1,2] QUE Zujun;LIU Jiajun;TIAN Jianhui(Institute of Oncology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Clinical Oncology Center,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院肿瘤研究所,上海200071 [2]上海中医药大学附属市中医医院肿瘤临床医学中心,上海200071

出　　处：《肿瘤防治研究》2023年第11期1127-1132,共6页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金面上项目(82174017,82174245);上海市中医医院未来计划科技发展项目(WL-HBRC-2021001K,WL-XJRY-2021002K)。

摘　　要：术后无症状的早期癌症(肺癌)患者的转移靶器官中已经潜伏有处于休眠状态的播散肿瘤细胞(DTCs),其增殖是导致临床转移发生的关键环节。开发维持DTCs休眠或根除休眠DTCs的治疗药物,将有望防治肿瘤的转移,进而突破恶性肿瘤整体疗效提高的瓶颈。本文对建立具有休眠特征的DTCs体内外研究模型的方法进行综述,以期促进学者对休眠DTCs的认识,提高抗肿瘤转移药物的研发效率。Postoperative asymptomatic patients with early cancer(lung cancer)have dormant disseminated tumor cells(DTCs)in their metastatic target organs,and the proliferation of these DTCs is the key link leading to clinical metastasis.The development of therapeutic agents to maintain DTCs dormant or eradicate dormant DTCs will prevent tumor metastasis and break through the bottleneck of improving the overall efficacy of treating malignant tumors.This paper reviews the methods of establishing in vitro and in vivo research models of DTCs with dormant characteristics to promote the understanding of dormant DTCs and improve the research and development efficiency of anti-tumor metastasis drugs.

关 键 词：肺癌转移 肿瘤休眠 播散肿瘤细胞 循环肿瘤细胞 研究模型 

分 类 号：R73-3[医药卫生—肿瘤]