血清NTX联合P1NP对乳腺癌患者骨转移的诊断价值  

Diagnostic value of serum N-terminal telopeptide of type I collagen(NTX)combined with procollagen type I N-terminal propeptide(P1NP)for bone metastasis patients with breast cancer

作　　者：王松龄 冒卫华 石晓红 陶佳慧 WANG Songling;MAO Weihua;SHI Xiaohong;TAO Jiahui(Department of Breast Surgery,Nantong City Rugao Traditional Chinese Medicine Hospital,Nantong Jiangsu 226500,China)

机构地区：[1]南通市如皋中医院甲乳外科,江苏南通226500

出　　处：《新疆医科大学学报》2023年第11期1485-1489,共5页Journal of Xinjiang Medical University

基　　金：江苏省卫生健康委员会医学科研项目(M2021114)。

摘　　要：目的探讨血清I型胶原吡啶交联氨基末端肽(N-terminal telopeptide of type I collagen,NTX)联合I型胶原氨基端延长肽(Procollagen type I N-terminal propeptide,P1NP)对乳腺癌患者骨转移的诊断价值。方法选择2018年3月至2023年1月南通市如皋中医院收治的女性乳腺癌骨转移患者72例(骨转移组)和单一乳腺癌患者72例(乳腺癌组),选择本院同期健康体检女性72例(健康组)。采用酶联免疫法检测并比较3组受试者血清NTX、P1NP表达水平的异同。分析血清NTX联合P1NP对乳腺癌患者骨转移的诊断价值,并采用Kappa检验分析血清指标诊断结果与临床诊断结果的一致性。结果骨转移组患者的血清NTX及P1NP水平高于乳腺癌组、健康组,乳腺癌组患者的血清NTX及P1NP水平高于健康组(P<0.05)。血清NTX、P1NP单一及联合诊断乳腺癌患者骨转移的曲线下面积(Area under curve,AUC)分别为0.794(95%CI:0.717~0.872)、0.789(95%CI:0.712~0.869)、0.875(95%CI:0.810~0.940),血清NTX、P1NP单一诊断乳腺癌患者骨转移的AUC均低于联合诊断(Z=3.971、4.025,P均<0.05)。血清NTX、P1NP单一及联合诊断乳腺癌患者骨转移与临床诊断结果一致性的Kappa值分别为0.597、0.556、0.750(P<0.05)。结论血清NTX、P1NP在乳腺癌骨转移中具有一定的辅助诊断价值,有助于早期甄别乳腺癌骨转移。Objective To investigate the diagnostic value of serum N-terminal telopeptide of type I collagen(NTX)combined with procollagen type I N-terminal propeptide(P1NP)in bone metastasis of breast cancer patients.Methods From March 2018 to January 2023,72 female patients with bone metastasis of breast cancer(bone metastasis group)and 72 patients with single breast cancer(breast cancer group)admitted to the hospital were selected,and 72 female patients with health examination in the same period(health group)were selected.Enzyme linked immunosorbent assay was used to detect and compare the expression levels of serum NTX and P1NP among the 3 groups of the subjects.To analyze the diagnostic value of serum NTX combined with P1NP in bone metastasis of breast cancer patients,and to analyze the consistency between serum biomarker diagnostic results and clinical diagnosis resultsby Kappa test.Results The serum levels of NTX and P1NP in the bone metastasis group were higher than those in the breast cancer group and healthy group(P<0.05).The serum levels of NTX and P1NP in the breast cancer group were higher than those in the healthy group(P<0.05).The areas under curve for the single and combined diagnosis of bone metastasis in breast cancer patients withusing serum NTX,P1NP were 0.794(95%CI:0.717-0.872),0.789(95%CI:0.712-0.869),and 0.875(95%CI:0.810-0.940),respectively.The areas under curve for the combined diagnosis was significantly higher than that for the single diagnosis of serum NTX and P1NP(Z=3.971,4.025,both P<0.05).The Kappa values for the consistency between the serum NTX,P1NP single and combined diagnosis of bone metastasis in breast cancer patients and the clinical diagnosis results were 0.597,0.556,and 0.750,respectively(P<0.05).Conclusion Serum NTX and P1NP have acertain value ofauxiliary diagnostic in bone metastasis ofbreast cancer,which ishelpfulfor early screening ofbone metastasis of breast cancer.

关 键 词：乳腺癌 骨转移 I型胶原吡啶交联氨基末端肽 I型胶原氨基端延长肽 诊断 

分 类 号：R737.9[医药卫生—肿瘤]