Pathological and immunohistochemical findings of lungs,heart,liver,and kidneys,and unexpected findings of fungi and parasites in lungs of deceased COVID-19 patients:A case series  

作　　者：Mehmet N.Yakar Bişar Ergün Aylin Erol Özde Gökbayrak TekincanÇ.Aktaş Özlem Ulusan Bağcı Fırat Bayraktar Eyüp S.Uçan Begüm Ergan Bilgin Cömert Ayşe Caner Safiye Aktaş Ali N.Gökmen 

机构地区：[1]Division of Intensive Care,Department of Anaesthesiology and Reanimation,Faculty of Medicine,Dokuz Eylül University,İzmir,Turkey [2]Division of Intensive Care,Department of Internal Medicine,Faculty of Medicine,Dokuz Eylül University,İzmir,Turkey [3]Department of Basic Oncology,Institute of Oncology,Dokuz Eylül University,İzmir,Turkey [4]Department of Basic Oncology,Institute of Health Sciences,Ege University,İzmir,Turkey [5]Department of Parasitology,Faculty of Medicine,Ege University,İzmir,Turkey [6]Division of Endocrinology and Metabolic Diseases,Department of Internal Medicine,Faculty of Medicine,Dokuz Eylül University,İzmir,Turkey [7]Department of Chest Diseases,Faculty of Medicine,Dokuz Eylül University,İzmir,Turkey

出　　处：《Journal of Acute Disease》2023年第5期204-212,I0001-I0003,共12页急性病杂志（英文版）

基　　金：Dokuz Eylül University Scientific Research Projects Coordination Unit funded the study(grant no.2020.KB.MLT.001).

摘　　要：Objective:To define histopathologic and immunohistochemical features of the lungs,heart,liver,and kidneys in patients who died from coronavirus disease 2019(COVID-19),and to determine the presence of SARS-CoV-2 in all tissues,as well as the presence of fungi and parasites in lung tissues.Methods:This retrospective case study was conducted in the intensive care units of Dokuz Eylül University Hospital,and patients(≥18 years)who died due to COVID-19 between October 2020 and April 2021 were included.The biopsy samples of the patient’s lung,heart,liver,and kidney tissues were studied.Results:In the study,we enrolled 12 patients(mean age:70 years;50%male).Alveolar epithelial cell damage and diffuse alveolar damage were predominant in lung tissues.Lobular lymphocyte infiltration,centrilobular sinusoidal dilatation,and microvesicular steatosis in the liver,together with pigmented cast,non-isometric vacuolar degeneration,and capillary plugging in the kidneys,were commonly found among the patients.SARS-CoV-2 nucleocapsid protein antibodies were detected in three lung and two kidney tissues,and so did angiotensin-converting enzyme 2 receptor positivity in one lung and more than half of the kidney tissues.The RT-PCR tests were positive in three lungs and one kidney tissue.After DNA isolation from lung tissues,Pneumocystis jirovecii was detected in nine patients,Aspergillus fumigatus in two,Microsporidia in three,and Cryptosporidium in two.Conclusions:SARS-CoV-2 is a multisystemic disease.Fungi and parasites should be investigated in critically ill COVID-19 patients prescribed corticosteroids.

关 键 词：Biopsy COVID-19 HISTOPATHOLOGY IMMUNOHISTO-CHEMISTRY Opportunistic infections SARS-CoV-2 

分 类 号：R730.51[医药卫生—肿瘤]