远视儿童短期使用1%阿托品凝胶后脉络膜厚度的变化  

Choroidal thickness changes in hyperopia children after short-term use of 1%atropine gel

作　　者：熊遥佳 周跃 尹卞宇 李俊杰 龚烨珣 孙志敏[1] 宋愈[1] XIONG Yaojia;ZHOU Yue;YIN Bianyu;LI Junjie;GONG Yexun;SUN Zhimin;SONG Yu(Nantong University Second Affiliated Hospital,Nantong 226006,China)

机构地区：[1]南通大学第二附属医院,南通226006

出　　处：《眼科学报》2023年第8期564-570,共7页Eye Science

基　　金：南通市科技计划(MS2020035)。

摘　　要：目的:评估远视儿童使用1%阿托品凝胶1周后脉络膜厚度(choroidal thickness,CT)的变化。方法:选择42例4~7岁的远视儿童,予每天使用1%阿托品凝胶两次,持续7 d。使用光学相干断层成像扫描测量视网膜及CT,并分析使用1%阿托品凝胶前后中心凹以及距中心凹处间隔1.0 mm的上、下、鼻和颞侧(最多3.0 mm)CT的变化。结果:在远视儿童中,基线CT随位置而变化(P<0.05),与中心凹相比,鼻侧及距中心凹上方2 mm、3 mm及距中心凹颞侧3 mm处的CT较薄(P<0.05)。使用1%阿托品凝胶后,中央凹及旁中心凹CT改变比较差异无统计学意义(P>0.05)。使用1%阿托品凝胶前后视网膜厚度无明显变化(P>0.05)。结论:短期使用1%阿托品凝胶并没有改变远视儿童的脉络膜和视网膜厚度。Objective:To assess changes of choroidal thickness(CT)in hyperopia children after 1 week using of 1%atropine.Methods:A total of 42 hyperopia children aged 4–7 years were included into the study.A single drop of 1%atropine gel was used twice a daily for 7 days in the subjects.The thickness of retina and choroid was measured by OCT,and the changes before and after using 1%atropine gel were analyzed at the subfoveal and at 1.0 mm intervals(up to 3.0 mm)from the fovea at superior,inferior,nasal,and temporal locations.Results:In the hyperopia children,baseline CT parameters were varied with the location(P<0.05).Compared with the fovea,the CT at the nasal side,2 mm and 3 mm above the fovea and 3 mm from the temporal side of the fovea were thinner(P<0.05).After using 1%atropine gel,there was no significant difference in the CT changes of subfoveal choroidal thickness and other sites of parafovea(P>0.05).There was no significant change in retinal thickness before and after using 1%atropine gel(P>0.05).Conclusion:No changes were found in the thickness of choroid and retina in hyperopia children after short-term use of 1%atropine gel.

关 键 词：阿托品 脉络膜厚度 远视 儿童 

分 类 号：R77[医药卫生—眼科]