重复经颅磁刺激联合齐拉西酮对康复期精神分裂症患者认知功能的疗效  

Efficacy of repetitive transcranial magnetic stimulation combined with ziprasidone on cognitive function in patients with convalescent schizophrenia

作　　者：崔翠翠 陈珍利 李翠鸾[3] 韩丽 吴雪飞 李晓靖 Cui Cuicui;Chen Zhenli;Li Cuiluan;Han Li;Wu Xuefei;Li Xiaojing(Sixth Department of Psychiatry,Shandong Mental Health Center,Jinan 250014,China;Department of Clinical Psychology,Shandong Mental Health Center,Jinan 250014,China;Day Diagnosis and Treatment Department,Shandong Mental Health Center,Jinan 250014,China;Department of Geriatrics,Shandong Mental Health Center,Jinan 250014,China;Sleep Medicine Department,Shandong Mental Health Center,Jinan 250014,China)

机构地区：[1]山东省精神卫生中心精神六科,济南250014 [2]山东省精神卫生中心临床心理科,济南250014 [3]山东省精神卫生中心日间诊疗科,济南250014 [4]山东省精神卫生中心老年科,济南250014 [5]山东省精神卫生中心睡眠医学科,济南250014

出　　处：《神经疾病与精神卫生》2023年第10期715-719,共5页Journal of Neuroscience and Mental Health

摘　　要：目的 分析重复经颅磁刺激(rTMS)联合齐拉西酮治疗康复期精神分裂症患者认知功能的效果。方法 选取2019年1月至2021年12月山东省精神卫生中心门诊收治的210例康复期精神分裂症患者为研究对象,采用随机数字表法随机分为对照组与观察组,每组105例。对照组服用齐拉西酮,观察组在对照组的基础上给予rTMS治疗,每组治疗12周。比较两组患者治疗前后的阳性与阴性症状量表(PANSS)评分、精神分裂症认知功能评测量表(SCoRS)评分以及药物不良反应量表(TESS)评分。结果 治疗12周后,观察组的治疗总有效率为89.52%(94/105),高于对照组的79.05%(83/105),差异有统计学意义(P<0.05)。两组患者治疗后的PANSS各分量表评分、SCoRS评分低于治疗前,且观察组的PANSS各分量表评分、SCoRS评分低于对照组,差异有统计学意义(P<0.05)。结论 rTMS联合齐拉西酮治疗康复期精神分裂症患者的效果较好,可有效改善患者的认知功能。Objective To explore the efficacy of repetitive transcranial magnetic stimulation(rTMS) combined with ziprasidone on cognitive function in patients with convalescent schizophrenia. Methods A total of 210 patients with convalescent schizophrenia admitted to the Outpatient Department of Shandong Mental Health Center from January 2019 to December 2021 were selected as the research subjects. The patients were randomly divided into a control group and an observation group by the random number table method, with 105 cases in each group. The patients of control group were treated with ziprasidone, while the patients of observation group were given rTMS on the basis of the control group, with each group receiving treatment for 12 weeks. The Positive and Negative Syndrome Scale(PANSS) scores and the Schizophrenia Cognition Rating Scale(SCoRS) scores before and after treatment, and the Treatment Emergent Symptom Scale(TESS) scores during treatment were compared between the two groups. Results After 12 weeks of treatment, the total effective rate of the observation group was 89.52%(94/105), higher than the control group's 79.05%(83/105), with a statistically significant difference(P < 0.05). The PANSS subscale scores and SCoRS scores of the two groups of patients after treatment were lower than those before treatment, and the PANSS subscale scores and SCoRS scores of the observation group after treatment were lower than those of the control group, with statistically significant differences(P < 0.05). Conclusions The combination of rTMS and ziprasidone has a significant efficacy in patients with convalescent schizophrenia, which can effectively improve their cognitive function.

关 键 词：精神分裂症 重复经颅磁刺激 齐拉西酮 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]