熊去氧胆酸联合胆管引流治疗胆道狭窄的临床分析  

Clinical analysis of ursodeoxycholic acid combined with bile duct drainage in the treatment of biliary stricture

作　　者：周政[1] 王光明[1] 刘有理[1] ZHOU Zheng;WANG Guangming;LIU Youli(Department of Gastroenterology of XuanCheng People's Hospital,Xuancheng 242000,Anhui Province,China)

机构地区：[1]安徽省宣城市人民医院消化内科,安徽宣城242000

出　　处：《世界临床药物》2023年第10期1050-1054,共5页World Clinical Drug

摘　　要：目的比较熊去氧胆酸联合胆道支架和单纯胆管支架引流治疗胆道狭窄的效果。方法收集自2019年6月至2021年6月期间因胆道狭窄来我院行内镜逆行胰胆管造影术(endoscopic retrograde cholangiopancreatography,ERCP)治疗的患者,分为试验组(熊去氧胆酸联合胆道支架治疗,158例)和对照组(胆道支架引流治疗,162例)。比较患者ERCP术前和术后的总胆红素(total bilirubin,TBIL)、丙氨酸转氨酶(alanine transaminase,ALT)水平,并发症情况,以及术后随访6个月的胆道狭窄复发情况。结果治疗后,两组TBIL、ALT水平均较治疗前明显下降(P<0.05),两组并发症的发生率比较,差异无统计学意义(P>0.05)。随访6个月,对照组的复发率高,差异有统计学意义(P<0.05)。结论两组治疗均可改善黄疸,且熊去氧胆酸联合胆道支架治疗的复发率更低。Objective To compare and analyze the effect of ursodeoxycholic acid combined with biliary stent drainage and biliary stent drainage alone in the treatment of biliary stricture.Methods Patients with biliary stricture who treated by endoscopic retrograde cholangiopancreatography(ERCP)in our hospital were collected from June 2019 to June 2021.The patients were divided into experimental group(ursodeoxycholic acid combined with biliary stent,158 cases)and control group(biliary stent,162 cases).The levels of total bilirubin(TBil)and alanine transaminase(ALT)before and after ERCP were analyzed.The complications were analyzed and the recurrence of biliary stricture was followed up for 6 months after ERCP.Results After treatment,the levels of TBil and ALT in the two groups were significantly lower than those before treatment(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).After 6 months of follow-up,the recurrence rate of biliary stricture in the control group was higher,and the difference was statistically significant(P<0.05).Conclusion Both two groups can reduce jaundice,and ursodeoxycholic acid combined with biliary stent has a lower recurrence rate in the treatment of biliary stricture.

关 键 词：经内镜逆行胰胆管造影术 胆道支架 熊去氧胆酸 胆道狭窄 

分 类 号：R575.7[医药卫生—消化系统] R453.9[医药卫生—内科学]