基于制剂工艺的掩味技术研究进展  

Advances in taste masking technology based on preparation technology

作　　者：赵磊 孔祥安妮 李畅 孙春萌 涂家生 ZHAO Lei;KONG Xiang-an-ni;LI Chang;SUN Chun-meng;TU Jia-sheng(Center for Drug Evaluation,National Medical Products Administration,Beijing 100022,China;NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients,and Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Department of Pharmaceutics,School of Pharmacy,Tianjin Medical University,Tianjin 300041,China)

机构地区：[1]国家药品监督管理局药品审评中心,北京100022 [2]国家药品监督管理局药物制剂及辅料研究与评价重点实验室,中国药科大学药学院药剂系,江苏南京210009 [3]天津医科大学药学院药剂学系,天津300041

出　　处：《药学学报》2023年第11期3185-3190,共6页Acta Pharmaceutica Sinica

摘　　要：良药苦口,但往往因为药物苦涩而难以下咽,使得患者用药顺应性差,而掩味技术的运用可以较好改善这一情况。合适有效的掩味技术能够改善患者尤其是儿童的用药顺应性,提高疗效,提高药物的临床价值。本文对掩味技术研究最新进展进行概括,从作用机制和应用范围等方面对传统掩味技术进行分类汇总,同时介绍了新型高效掩味技术。Good medicine tastes bitter,but it is often difficult to swallow because the drug is bitter and astringent,so that the compliance of patients with medication is poor.However,the use of taste masking technology can better improve this situation.Appropriate and effective taste masking technology can improve the drug compliance of patients,especially children,it can also improve the curative effect and the clinical value of drugs.Herein,we summarize the latest research progress of taste masking technology,and summarize the traditional taste masking technology from the aspects of action mechanisms and application scopes.Finally,the novel and efficient taste masking technologies were presented.

关 键 词：掩味技术 药用辅料 掩味原理 儿童制剂 

分 类 号：R944[医药卫生—药剂学]