突触结合蛋白家族成员调控恶性肿瘤发展的研究进展  

Research Progression of Synaptotagmins Family Members in Regulating the Development of Malignancies

作　　者：任粤 陈勇[1] 杜雷亚[2] 殷旭东 REN Yue;CHEN Yong;DU Leiya;YIN Xudong(Department of Oncology,Affiliated Hospital of Yangzhou University,Yangzhou,225000;Department of Oncology,Yibin Second People's Hospital,Yibin,644000)

机构地区：[1]扬州大学附属医院肿瘤科,扬州225000 [2]宜宾市第二人民医院肿瘤科,宜宾644000

出　　处：《基因组学与应用生物学》2023年第10期1028-1037,共10页Genomics and Applied Biology

基　　金：江苏省自然科学基金项目(BK20191218);扬州市科技计划项目(YZ2021081);2022年江苏省研究生实践创新计划(SJCX_1818)共同资助。

摘　　要：突触结合蛋白能通过依赖钙离子的经典途径和不依赖钙离子的非经典途径介导膜融合,从而调控细胞分泌活动。随着生物信息学的发展,研究人员发现突触结合蛋白家族成员不仅在神经系统和内分泌系统中发挥了重要的生物学功能,还能调控恶性肿瘤的发生发展。在本文中,作者结合目前关于突触结合蛋白家族的生物学功能和生物信息学分析,总结其在恶性肿瘤中的作用和机制,并探讨了该家族未来的研究方向。The synaptotagmin regulate cellular secretory activity by mediating membrane fusion through classical calcium ion-dependent and non-classical calcium ion-independent pathways.With the development of bioinformatics,researchers have found that this family of proteins not only plays vital biological functions in the nervous and endocrine systems but also plays acritical roles in the regulation of malignancy development.In this review,the biological functions and bioinformatics analysis of the synaptotagmin family are integrated to summarize their functions and mechanisms in malignancy.Future research directions of this family are discussed.

关 键 词：突触结合蛋白家族 恶性肿瘤 细胞分泌 

分 类 号：R730.2[医药卫生—肿瘤]