单细胞测序在胃肠道肿瘤中的应用  

Application of single cell sequencing in gastrointestinal tumors

作　　者：熊斌[1] 许文悦 麦麦提吐孙·玉苏普 Xiong Bin;Xu Wenyue;Maimaititusun Yusupu(Department of Gastrointestinal Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071 China)

机构地区：[1]武汉大学中南医院胃肠外科,湖北武汉430071

出　　处：《实用肿瘤杂志》2023年第6期518-522,共5页Journal of Practical Oncology

摘　　要：胃肠道肿瘤是最常见的消化系统恶性肿瘤,主要包括胃癌和结直肠癌。单细胞测序技术在胃肠道肿瘤中运用广泛,主要集中应用于癌前病变、肿瘤来源、肿瘤细胞异质性、免疫治疗、肿瘤微环境和肿瘤转移等,是胃肠道肿瘤研究的有力工具。本文就单细胞测序在胃肠道肿瘤中的应用进展、局限性和未来探索方向进行述评,期望为胃肠道肿瘤的研究、诊断与治疗提供新思路。Gastrointestinal tumors are the most common malignant tumors of the digestive system,mainly including gastric cancer and colorectal cancer.Single-cell sequencing technology has been widely used in gastrointestinal tumors,mainly focusing on precancerous lesions,tumor origin,tumor cell heterogeneity,immunotherapy,tumor microenvironment and tumor metastasis.It has been a powerful tool for the research on gastrointestinal neoplasms.This article reviews the progress,limitations and future exploration directions of the application of single cell sequencing in gastrointestinal neoplasms,hoping to provide new ideas for the research,diagnosis and treatment of gastrointestinal neoplasms.

关 键 词：胃肠道肿瘤 单细胞测序 肿瘤微环境 肿瘤转移 免疫治疗 

分 类 号：R735[医药卫生—肿瘤]