Helicobacter pylori infection in Xinjiang Uyghur Autonomous Region:Prevalence and analysis of related factors  

作　　者：Yu-Hua Peng Xue Feng Zhong Zhou Lei Yang Yun-Fei Shi 

机构地区：[1]Department of Pathology,Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region,The Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,Urumqi 830000,Xinjiang Uygur Autonomous Region,China [2]Department of Laboratory Medicine,Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region,The Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,Urumqi 830000,Xinjiang Uygur Autonomous Region,China [3]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Beijing Office for Cancer Prevention and Control,Peking University Cancer Hospital&Institute,Beijing 100142,China [4]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Pathology,Peking University Cancer Hospital&Institute,Beijing 100142,China

出　　处：《World Journal of Gastroenterology》2023年第43期5834-5847,共14页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND^(14)C urea breath test(^(14)C UBT)and immunohistochemical staining(IHC)are widely used for detection Helicobacter pylori(H.pylori)infection with different sensitivity,and there is a difference in H.pylori infection rate in Uyghur and Han ethnic groups.Both need large cohort studies to evaluate the differences more accurately.AIM To analyze the difference between^(14)C UBT and IHC for H.pylori detection in Xinjiang Uyghur Autonomous Region and the difference between Uyghur and Han populations.METHODS There were 3944 cases of H.pylori infection detected by both IHC and^(14)C UBT at the same time(interval<1 wk,with sampling site including gastric antrum,selected from 5747 patients).We compared the sensitivity of^(14)C UBT and IHC.We also compared 555 pairs of Han/Uyghur cases(completely matched for gender and age)for their H.pylori infection rates.The overall H.pylori infection rate of all 5747 cases and the correlation with other clinicopathological data were also further analyzed.SPSS V23.0 software was used for statistical analysis.RESULTS The sensitivity was 94.9%for^(14)C UBT and 65.1%for IHC,which was a significant difference(n=3944,P<0.001).However,among those cases negative for H.pylori by^(14)C UBT(detection value≤100),4.8%were positive by IHC.Combining both methods,the overall H.pylori infection rate was 48.6%(n=5747),and differences in gender,age group,ethnicity and region of residence significantly affected the H.pylori positive rates.According to age group(Han/Uyghur),the positive rates were≤30 years(62.2%/100.0%),31-40 years(45.2%/85.7%),41-50 years(47.2%/79.2%),51-60 years(44.6%/76.1%),61-70 years(40.9%/68.2%),71-80 years(41.7%/54.1%)and≥81 years(42.9%/NA).The H.pylori infection rates of Han/Uyghur paired cases were 41.4%and 73.3%,which was a significant difference(P<0.001)(555 pairs).H.pylori positivity was significantly related to moderate-severe grade 2-3 chronic/active gastritis and intestinal metaplasia(all P<0.05).CONCLUSION The sensitivity of^(14)C UBT was significantly higher,

关 键 词：Helicobacter pylori IMMUNOHISTOCHEMISTRY 14C urea breath test HAN UYGHUR Xinjiang Uyghur Autonomous Region 

分 类 号：R573.3[医药卫生—消化系统] R735.34[医药卫生—内科学]