Colorectal motility patterns and psychiatric traits in functional constipation and constipation-predominant irritable bowel syndrome:A study from China  

作　　者：Chao-Lan Lv Geng-Qing Song Jie Liu Wei Wang Yi-Zhou Huang Bo Wang Jia-Shuang Tian Meng-Qing Yin Yue Yu 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,Anhui Province,China [2]Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,Anhui Province,China [3]Department of Gastroenterology and Hepatology,Metrohealth Medical Center,Case Western Reserve University,Cleveland,OH 44109,United States [4]Department of Gastroenterology,Affiliated Anhui Provincial Hospital,Anhui Medical University,Hefei 230001,Anhui Province,China [5]Department of Gastroenterology,Graduate School of Bengbu Medical College,Bengbu 233000,Anhui Province,China

出　　处：《World Journal of Gastroenterology》2023年第41期5657-5667,共11页世界胃肠病学杂志（英文版）

基　　金：the External Science and Technology Cooperation Planning Projects of Anhui Province of China,No.1604b060202.

摘　　要：BACKGROUND Functional constipation(FC)and constipation-predominant irritable bowel syndrome(IBS-C)represent a spectrum of constipation disorders.However,the majority of previous clinical investigations have focused on Western populations,with limited data originating from China.AIM To determine and compare the colorectal motility and psychiatric features of FC and IBS-C in an Eastern Chinese population.METHODS Consecutive chronic constipation patients referred to our motility clinic from December 2019 to February 2023 were enrolled.FC and IBS-C diagnoses were established using ROME IV criteria,and patients underwent high-resolution anorectal manometry(ARM)and a colonic transmit test using the Sitz marker study.Constipation-related symptoms were obtained through questionnaires.Anxiety and depression were assessed by the Hamilton anxiety rating scale and the Hamilton Depression Rating Scale-21.The clinical characteristics and colorectal motility patterns of FC and IBS-C patients were compared.RESULTS No significant differences in sex,age or abdominal discomfort symptoms were observed between IBS-C and FC patients(all P>0.05).The proportion of IBS-C patients with delayed colonic transit was higher than that of patients with FC(36.63%vs 15.91%,P<0.05),while rectosigmoid accumulation of radiopaque markers was more common in the FC group than in the IBS-C group(50%vs 26.73%,P<0.05).Diverse proportions of these dyssynergic patterns were noted within both the FC and IBS-C groups by ARM.IBS-C patients were found to have a higher prevalence of depression than FC patients(66.30%vs 42.42%,P<0.05).The scores for feelings of guilt,suicide,psychomotor agitation,diurnal variation,obsessive/compulsive disorder,hopelessness,self-abasedment and gastrointestinal symptoms were significantly higher in IBS-C patients than that in FC patients(P<0.05).For IBS-C(χ^(2)=5.438,P<0.05)but not FC,patients with normal colon transit time were significantly more likely to have anxiety than those with slow colon transit time.For IBS-C patients bu

关 键 词：Functional constipation Constipation-predominant irritable bowel syndrome High-resolution anorectal manometry Colonic transmit test ANXIETY Depression 

分 类 号：R574[医药卫生—消化系统]