Risk factors for anastomotic fistula development after radical colon cancer surgery and their impact on prognosis  

作　　者：Jun Wang Min-Hua Li 

机构地区：[1]Department of Gastrointestinal Surgery,The Affiliated Hospital of Jiangnan University,Wuxi 214000,Jiangsu Province,China [2]Department of Gastroenterology,The Affiliated Hospital of Jiangnan University,Wuxi 214000,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第11期2470-2481,共12页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Colon cancer is a common malignant tumor in the gastrointestinal tract that is typically treated surgically.However,postradical surgery is prone to complic-ations such as anastomotic fistulas.AIM To investigate the risk factors for postoperative anastomotic fistulas and their impact on the prognosis of patients with colon cancer.METHODS We conducted a retrospective analysis of 488 patients with colon cancer who underwent radical surgery.This study was performed between April 2016 and April 2019 at a tertiary hospital in Wuxi,Jiangsu Province,China.A t-test was used to compare laboratory indicators between patients with and those without postoperative anastomotic fistulas.Multiple logistic regression analysis was performed to identify independent risk factors for postoperative anastomotic fistulas.The Functional Assessment of Cancer Therapy-Colorectal Cancer was also used to assess postoperative recovery.RESULTS Binary logistic regression analysis revealed that age[odds ratio(OR)=1.043,P=0.015],tumor,node,metastasis stage(OR=2.337,P=0.041),and surgical procedure were independent risk factors for postoperative anastomotic fistulas.Multiple linear regression analysis showed that the development of postoperative anastomotic fistula(P=0.000),advanced age(P=0.003),and the presence of diabetes mellitus(P=0.015),among other factors,independently affected CONCLUSION Postoperative anastomotic fistulas significantly affect prognosis and survival rates.Therefore,focusing on the clinical characteristics and risk factors and immediately implementing individualized preventive measures are important to minimize their occurrence.

关 键 词：Radical colon cancer surgery Anastomotic fistula Risk factors PROGNOSIS Life expectancy Survival rate 

分 类 号：R735.34[医药卫生—肿瘤]