八味解郁汤加减联合艾司西酞普兰治疗肝郁脾虚证轻中度抑郁症临床研究  

Clinical Study on Modified Bawei Jieyu Decoction Combined with Escitalopram for Mild and Moderate Depression with Liver Constraint and Spleen Deficiency Syndrome

作　　者：刘永兵 张雪 皇甫菲菲 LIU Yongbing;ZHANG Xue;HUANGFU Feifei(Department of Integrated Traditional Chinese and Western Medicine,Jiaozuo City Mental Hospital,Jiaozuo Henan 454000,China)

机构地区：[1]焦作市精神病院中西医结合科,河南焦作454000

出　　处：《新中医》2023年第21期46-49,共4页New Chinese Medicine

摘　　要：目的:观察八味解郁汤加减联合艾司西酞普兰治疗肝郁脾虚证轻中度抑郁症患者的疗效及对腺嘌呤核苷三磷酸(ATP)、腺嘌呤核苷二磷酸(ADP)、腺嘌呤核糖核苷酸(AMP)的影响。方法:选取104例郁脾虚型轻中度抑郁症患者,按照随机数字表法分为观察组和对照组各52例。对照组给予艾司西酞普兰治疗,观察组给予八味解郁汤加减联合艾司西酞普兰治疗。比较2组临床疗效,比较2组治疗前后中医证候积分、汉密尔顿量表评分(HAMD-24)及ATP、ADP、AMP水平。结果:治疗后,观察组总有效率94.23%,高于对照组80.77%(P<0.05)。治疗后,2组胁胀作痛、情志抑郁、腹胀、便溏等中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组HAMD-24评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,对照组AMP水平升高(P<0.05),观察组ATP水平升高(P<0.05);且观察组AMP、ADP水平低于对照组(P<0.05),ATP水平高于对照组(P<0.05)。结论:八味解郁汤加减联合艾司西酞普兰有利于改善轻中度抑郁症肝郁脾虚症患者的抑郁症状,疗效佳,且可有效提高ATP含量。Objective:To observe the curative effect of modified Bawei Jieyu Decoction combined with Escitalopram for mild and moderate depression with liver constraint and spleen deficiency syndrome and its effects on adenosine triphosphate(ATP),adenosine diphosphate(ADP),and adenosine monophosphate(AMP).Methods:A total of 104 cases of patients with mild and moderate depression with liver constraint and spleen deficiency syndrome were selected and divided into the observation group and the control group according to the random number table method,with 52 cases in each group.The control group was treated with Escitalopram,and the observation group was treated with modified Bawei Jieyu Decoction combined with Escitalopram.Clinical effects were compared between the two groups.Traditional Chinese medicine(TCM)syndrome scores,scores of 24-item Hamilton Depression Rating Scale(HAMD-24),and levels of ATP,ADP,and AMP were compared before and after treatment between the two groups.Results:After treatment,the total effective rate was 94.23%in the observation group,higher than that of 80.77%in the control group(P<0.05).After treatment,the TCM syndrome scores of rib-side distension and pain,depressive emotion,abdominal distension,and loose stool in the two groups were decreased(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).After treatment,HAMD-24 scores in the two groups were decreased(P<0.05),and HAMD-24 scores in the observation group were lower than those in the control group(P<0.05).After treatment,AMP level in the control group was increased(P<0.05),ATP level in the observation group was increased(P<0.05),and the levels of AMP and ADP in the observation group were lower than those in the control group(P<0.05),and ATP level in the observation group was higher than that in the control group(P<0.05).Conclusion:Modified Bawei Jieyu Decoction combined with Escitalopram has good curative effects in the treatment of patients with mild and moderate depression with liver constraint and s

关 键 词：轻中度抑郁症 肝郁脾虚证 八味解郁汤加减 艾司西酞普兰 线粒体 腺嘌呤核苷三磷酸 

分 类 号：R749.4[医药卫生—神经病学与精神病学]