结直肠癌转移调控的环状RNA分子机制研究进展  

The progress in research of molecular mechanism of circRNAs regulating colorectal cancer metastasis

作　　者：范博洋 王宁[2] 张骞 王贵玉[1] Fan Boyang;Wang Ning;Zhang Qian;Wang Guiyu(Department of Colorectal Cancer Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China,Key Laboratory of Cardiovascular Medicine Research,Ministry of Education),College of Pharmacy,Harbin Medical University,Harbin 150081,China;Department of Colorectal Surgery,Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Hangzhou 310000,China)

机构地区：[1]哈尔滨医科大学附属第二医院结直肠肿瘤外科,150086 [2]哈尔滨医科大学药学院药学系(国家生物医药药物重点实验室,心血管药物研究教育部重点实验室),150081 [3]中国科学院大学附属肿瘤医院(浙江省肿瘤医院)结直肠外科,310000

出　　处：《中华结直肠疾病电子杂志》2023年第5期426-430,共5页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金(62276084)。

摘　　要：结直肠癌是全球癌症致死的第三大病因,其具有高复发率和高转移率的特点,该特性也是结直肠癌预后不良的主要原因。但迄今为止,结直肠癌发生转移的分子调控机制仍不完全清楚。因此,该领域已成为当前国内外研究学者的关注热点。目前研究发现,多种非编码RNA在肿瘤等疾病的发生和发展过程中发挥重要的调控作用。本文通过分析在结直肠癌转移的病理生理过程中,非编码RNA家族成员-环状RNA(circRNAs)的生物学活性及其分子调控机制的最新研究进展,初步建立结直肠癌转移相关信号通路的circRNAs调控网络。进一步分析circRNAs作为新型的结直肠癌诊断和预后生物标志物及治疗靶点的临床应用转化潜力,为临床治疗结直肠癌提供新思路和新靶点。Colorectal cancer is the third leading cause of cancer deaths worldwide, with its high recurrence and metastasis rates being the main reasons for poor prognosis. Therefore, the regulatory mechanism of colorectal cancer metastasis has become a hot topic of interest for domestic and international researchers. To date, however, the potential regulatory mechanisms of colorectal cancer metastasis remain incompletely understood. Many non-coding genes are involved in tumor invasion and spread, with circular RNAs (circRNAs) being important non-coding RNAs. CircRNAs may be involved in the colorectal carcinogenesis and metastasis. In this review, we systematically analyze the latest research on the role of circRNAs to regulate metastasis-related signaling pathways and the involvement of these circRNAs in colorectal cancer promotion and suppression. The regulatory network of circRNAs in the colorectal metastasis-related signaling pathway has been determined. Further analysis of the potential clinical applications of circRNAs as novel clinical diagnostic and prognostic biomarkers and therapeutic targets for colorectal cancer may provide new ideas and solutions for the prevention and treatment of colorectal cancer.

关 键 词：结直肠肿瘤 转移 环状RNA 信号通路 

分 类 号：R735.34[医药卫生—肿瘤]