光动力疗法治疗下生殖道鳞状上皮内病变的研究进展  

Photodynamic therapy for squamous intraepithelial lesions of the lower reproductive tract

作　　者：李思婧 贾英[1] LI Sijing;JIA Ying(Department of Obstetrics and Gynecology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400000,China)

机构地区：[1]重庆医科大学附属第一医院妇产科,重庆400000

出　　处：《中华实用诊断与治疗杂志》2023年第11期1181-1184,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：重庆市技术创新与应用发展专项重点项目(CSTB2022TIADKPX0159);重庆市教育委员会科学技术研究项目(KJZD-K202200407)。

摘　　要：下生殖道鳞状上皮内病变(SIL)是一类与高危型人乳头瘤状病毒持续感染密切相关的病变,分为低级别SIL和高级别SIL,近年发病呈年轻化趋势。冷冻、激光、手术等方法治疗SIL效果确切,但为有创治疗,治疗后可能出现出血、宫颈粘连、妊娠后流产、早产等并发症。SIL的治疗药物大多是改善宫颈局部免疫环境而不能清除病毒。对有生育需求的SIL患者,保护生育功能的同时寻求一种安全、有效、无创的方法来促进SIL逆转有重要意义。光动力疗法是通过光动力学反应选择性破坏病变组织,治疗SIL有较好效果。本文就光动力疗法治疗SIL的研究进展作一综述。Squamous intraepithelial lesion(SIL)of the lower reproductive tract is closely correlated with persistent high-risk human papillomavirus infection,which is divided into low-and high-grade SIL,and its incidence has been showing younger trend in recent years.Cryotherapy,laser,surgery and other methods are effective for SIL,but they are invasive,and the complications after treatment may occur as bleeding,cervical adhesion,abortion after pregnancy,and preterm birth.Most conservative treatment drugs can improve the local immune environment of the cervix but cannot eliminate the virus.For SIL patients with fertility needs,it is of great significance to seek a safe,effective and non-invasive method to promote SIL reversal while protecting their reproductive function.Photodynamic therapy can selectively destroy the diseased tissue through photodynamic reaction to achieve the purpose of treatment,and the good results have also been achieved in the treatment of SIL.This paper reviews the research progress of photodynamic therapy in the treatment of SIL.

关 键 词：鳞状上皮内病变 下生殖道 人乳头瘤状病毒 女性 光动力疗法 

分 类 号：R737.33[医药卫生—肿瘤]