蛋白质精氨酸甲基转移酶在血液肿瘤疾病中的作用研究进展  

Progress on the role of PRMTs in hematological malignancy diseases

作　　者：何红波(综述) 郑胡镛(审校)[1] He Hongbo;Zheng Huyong(Hematology Center,Beijing Key Laboratory of Pediatric Hematology Oncology National Key Clinical Discipline of Pediatric Hematology,National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in Children,Ministry of Education Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院血液病中心,儿童血液病与肿瘤分子分型北京市重点实验室,儿童血液病国家临床重点专科,儿科学国家重点学科,儿科重大疾病研究教育部重点实验室,100045

出　　处：《国际儿科学杂志》2023年第9期590-594,共5页International Journal of Pediatrics

基　　金：国家自然科学基金(82070154);北京自然科学基金(7222056);首都卫生发展科研专项(首发2022-1-2091)。

摘　　要：蛋白质精氨酸甲基转移酶(protein arginine methyltransferases,PRMTs)家族具有广泛的分子功能,在干细胞发育系统中参与造血细胞的发生、发育、增殖和分化。在血液肿瘤疾病中,PRMTs可通过甲基化途径参与许多重要的生物学过程,包括细胞增殖、细胞周期控制、基因转录、DNA损伤修复。PRMTs的异常表达可导致肿瘤的发生与发展,特别是在儿童白血病中,通过靶向PRMTs治疗,降低PRMTs的表达,可以有效地抑制肿瘤细胞的增殖和存活。因此,PRMTs与血液肿瘤疾病的关系备受关注,未来很可能成为治疗的一个重要靶标。该文对PRMTs在血液肿瘤疾病中的作用及其机制作一综述,以期为血液肿瘤疾病的治疗提供新的思路。The protein arginine methyltransferases(PRMTs)family has a wide range of molecular functions and is involved in the generation,development,proliferation and differentiation of hematopoietic cells in the stem cell development.In hematological malignancy diseases,PRMTs can be involved in many important biological processes including cell proliferation,cell cycle,gene transcription,and DNA damage repair through methylation pathways.The abnormal expression of PRMTs can lead to the occurrence and development of malignancy diseases,especially in childhood leukemia.Targeted PRMTs therapy can effectively inhibit the proliferation and survival of tumor cells by reducing the expression of PRMTs.Therefore,the relationship between PRMTs and hematological malignancy diseases has received much attention and is likely to become an important target for treatment in the future.This article reviews the role and mechanism of PRMTs in hematological malignancy diseases,in order to provide new strategies for the treatment of hematological malignancy diseases.

关 键 词：蛋白质精氨酸甲基转移酶 血液肿瘤疾病 

分 类 号：R733[医药卫生—肿瘤]