反刍思维在成年癫痫患者焦虑抑郁与生活质量间的中介效应  

Mediating effect of rumination on anxiety,depression and quality of life in adult patients with epilepsy

作　　者：乔保俊 徐冉冉 张亮[1] 颜辉 李焕霞 郝延磊[1,2] Qiao Baojun;Xu Ranran;Zhang Liang;Yan Hui;Li Huanxia;Hao Yanlei(Department of Neurology,Affiliated Hospital of Jining Medical University,Jining 272100,China;Department of Neurology,Ningbo Taikang Brain Hospital,Ningbo 315000,China)

机构地区：[1]济宁医学院附属医院神经内科,济宁272100 [2]宁波泰康脑科医院神经内科,宁波315000

出　　处：《中华行为医学与脑科学杂志》2023年第11期1005-1010,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81771360);济宁市重点研发计划(2022JNZC118)。

摘　　要：目的探索反刍思维在成人癫痫患者焦虑抑郁与生活质量间的中介效应。方法采用反刍思维量表(ruminative responses scale,RRS)、癫痫抑郁量表(neurological disorders depression inventory for epilepsy,NDDI-E)、广泛性焦虑量表(generalized anxiety disorder,GAD-7)、成人癫痫患者生活质量量表(quality of life scale for adult epilepsy patients,QOLIE-31)中文版和自编的一般情况问卷对济宁医学院附属医院就诊的118例成年癫痫患者进行问卷调查。采用SPSS 20.0统计软件对反刍思维、生活质量、焦虑抑郁评分进行Pearson相关分析,中介效应分析检验采用层级回归方法。结果 118例成年癫痫患者反刍思维高水平(RRS=66~88分)、中等水平(RRS=44~65分)、低水平(RRS=22~43分)的患者分别为5例(4.24%)、58例(49.15%)、55例(46.61%)。Pearson相关分析结果显示,癫痫患者反刍思维及各维度得分与生活质量呈显著负相关(r=-0.411~-0.318,均P<0.05);与焦虑得分呈显著正相关(r=0.524~0.676,均P<0.05),与抑郁得分呈显著正相关(r=0.566~0.767,均P<0.05);层级回归分析结果显示,反刍思维在焦虑和生活质量以及抑郁和生活质量的关系中存在部分中介效应,中介效应值分别为-0.201和-0.215。结论焦虑抑郁可通过反刍思维影响成年癫痫患者的生活质量。Objective To explore the mediating effect between anxiety,depression and quality of life in adult patients with epilepsy.Methods A total of 118 adult patients with epilepsy from Affiliated Hospital of Jining Medical University were investigated with the ruminative responses scale(RRS),neurological disorders depression inventory for epilepsy(NDDI-E),generalized anxiety disorder(GAD-7),quality of life scale for adult epilepsy patients(QOLIE-31 Chinese Version)and the self-made general situation questionnaire.Statistical analysis was performed by SPSS 20.0 software.Pearson correlation analysis was employed to assess the relationships between rumination,quality of life,anxiety,and depression scores.Hierarchical regression analysis was employed to examine the mediating effect.Results Among the 118 participants,5(4.24%),58(49.15%),and 55(46.61%)patients exhibited high(RRS=66-88),middle(RRS=44-65),and low(RRS=22-43)level of rumination,respectively.Pearson correlation analysis revealed significantly negative correlations between the scores of rumination and its dimensions and quality of life in patients with epilepsy(r=-0.411--0.318,all P<0.05).Additionally,there were significantly positive correlations between the scores of rumination and its dimensions and anxiety scores(r=0.524-0.676,all P<0.05)and depression scores(r=0.566-0.767,all P<0.05).Hierarchical regression analysis demonstrated that rumination played partially mediating role in the relationship between anxiety and quality of life,as well as the relationship between depression and quality of life,with mediation effect values of-0.201 and-0.215,respectively.Conclusion Anxiety and depression can affect the quality of life of adult patients with epilepsy through rumination.

关 键 词：反刍思维 癫痫 焦虑 抑郁 生活质量 中介效应 

分 类 号：R742.1[医药卫生—神经病学与精神病学]