134例儿童神经母细胞瘤的临床分析  

Clinical analysis of 134 cases of neuroblastoma in children

作　　者：贺晶[1] 李佳倬 田鑫[1] 陈可可[1] 邹润英[1] 朱呈光[1] 贺湘玲[1] HE Jing;LI Jiazhuo;TIAN Xin;CHEN Keke;ZOU Runying;ZHU Chengguang;HE Xiangling(Department of Pediatric Hematology Oncology,Hunan Provincial People's Hospital,the First Affiliated Hospital of Hunan Normal University,Hunan Changsha 410005,China)

机构地区：[1]湖南师范大学附属第一医院湖南省人民医院儿童血液肿瘤科,湖南长沙410005

出　　处：《现代肿瘤医学》2023年第23期4356-4361,共6页Journal of Modern Oncology

摘　　要：目的:分析神经母细胞瘤(neuroblastoma,NB)患儿的一般资料、临床资料、治疗情况和预后,为NB的临床诊治提供参考依据。方法:回顾性分析2016年01月至2022年12月134例在我院治疗及随访的NB患儿的一般资料、临床资料,统计并分析无事件生存期(event free survival,EFS)及总生存期(overall survival,OS)。结果:134例研究对象,男∶女=1.6∶1,中位起病年龄为3.0岁,82.6%的患儿发病年龄≤5岁。肿瘤原发部位大多数起源于腹部,共109例(81.3%)。首发症状以发热居多,共36例(26.9%),其次是体检发现纵隔肿物或腹部包块共31例(23.1%)。65.5%高危NB患儿出现淋巴结转移。93.2%的患儿存在LDH值升高,高危组LDH值最高,不同危险度组间比较LDH值差异有统计学意义(P<0.05)。86.5%的患儿存在NSE值增高,42.1%(48例)的患儿存在尿VMA值增高,不同危险度组间比较NSE值、VMA值差异无统计学意义(P>0.05)。完成完整治疗的125例患儿整体5年EFS为46.5%,OS为72.0%;高危患儿5年EFS为25.1%,OS为63.6%。结论:NB肿瘤原发部位多来源于腹部,发热常为首发症状。125例完成完整治疗的NB患儿经多学科综合诊治5年EFS为46.5%,OS为72.0%,其中高危患儿5年EFS为25.1%,OS为63.6%。Objective:To analyze the general information,clinical data,treatment status,and prognosis of children with neuroblastoma(NB),in order to provide reference for the clinical diagnosis and treatment of NB.Methods:A retrospective analysis was conducted on 134 pediatric patients with NB who were treated and followed up in our hospital from January 2016 to December 2022.General and clinical data of the patients were collected,and event free survival(EFS)and overall survival(OS)were statistically analyzed.Results:134 subjects were included in the study,with a male and female ratio of 1.6∶1,and a median onset age of 3.0 years old.82.6%of the patients had onset age≤5 years old.The majority of tumors originated from the abdomen in 109 cases(81.3%).The first symptom was mostly fever in 36 cases(26.9%),followed by 31 cases(23.1%)of mediastinal masses or abdominal masses found during physical examination.65.5%of high-risk NB patients had lymph node metastasis.93.2%of the children had elevated LDH values,with the highest LDH value in the high-risk group.There was a statistically significant difference in LDH values between different risk groups(P<0.05).86.5%of the children had an increase in NSE value,while 42.1%(48 cases)had an increase in urinary VMA value.There was no statistically significant difference in NSE and VMA values among different risk groups(P>0.05).The overall 5-year EFS of 125 children who completed complete treatment was 46.5%,and OS was 72.0%.High-risk children had a 5-year EFS of 25.1%and OS of 63.6%.Conclusion:The primary site of tumors mostly comes from the abdomen,and fever is often the first symptom.After multidisciplinary comprehensive diagnosis and treatment,the 5-year EFS was 46.5%and 5-year OS was 72.0%in 125 NB children who completed complete treatment.And among these high-risk children,the 5-year EFS is 25.1%and 5-year OS is 63.6%.

关 键 词：神经母细胞瘤 儿童 临床分析 

分 类 号：R739.4[医药卫生—肿瘤]