肝炎后肝硬化患者食管静脉曲张出血发生情况及影响因素  

Occurrence Situation of Esophageal Variceal Bleeding and Influencing Factors of Patients with Posthepatitic Cirrhosis

作　　者：欧阳峰 吕美光 OUYANG Feng;LYU Meiguang(Lianzhou People's Hospital,Guangdong Province,Lianzhou 513400,China;不详)

机构地区：[1]广东省连州市人民医院,广东连州513400

出　　处：《中国医学创新》2023年第31期130-134,共5页Medical Innovation of China

基　　金：2018年清远市社会发展领域自筹经费科技计划项目(2018B157)。

摘　　要：目的:研究分析肝炎后肝硬化患者食管静脉曲张出血发生情况及影响因素。方法:采用随机抽样法选取2014年4月—2022年5月连州市人民医院的225例肝炎后肝硬化患者为研究对象进行回顾性分析,统计食管静脉曲张出血发生率,同时比较不同性别、年龄、血红蛋白水平、白蛋白水平、Child-Pugh分级、消化性溃疡情况、食管静脉曲张程度、血小板计数、腹水情况、门静脉直径、脾厚度和有无消化道出血史及门静脉栓子者的食管静脉曲张出血发生率,采用多因素logistic回归分析肝炎后肝硬化患者食管静脉曲张出血发生的影响因素。结果:225例肝炎后肝硬化患者中发生61例食管静脉曲张出血,发生率为27.11%,不同性别、年龄及脾厚度患者的食管静脉曲张出血发生率比较,差异均无统计学意义(P>0.05),血红蛋白水平<110 g/L、白蛋白水平<30 g/L、Child-Pugh分级B级及C级、消化性溃疡、食管静脉曲张直径>6 mm、血小板计数<100×10^(9)/L、腹水、门静脉直径≥1.5 cm、消化道出血史及门静脉栓子患者的食管静脉曲张出血发生率均显著高于其他患者,差异均有统计学意义(P<0.05),多因素logistic回归分析显示,血红蛋白水平、白蛋白水平、Child-Pugh分级、消化性溃疡、食管静脉曲张程度、血小板计数、腹水、门静脉直径、消化道出血史及门静脉栓子均是肝炎后肝硬化患者食管静脉曲张出血发生的影响因素(P<0.05)。结论:肝炎后肝硬化患者食管静脉曲张出血发生率较高,且本类患者食管静脉曲张出血发生的影响因素较多,可将其作为出血防控措施制定的参考依据。Objective:To study and analyze the occurrence situation of esophageal variceal bleeding and influencing factors of patients with posthepatitic cirrhosis.Method:A total of 225 patients with posthepatitic cirrhosis in Lianzhou People's Hospital from April 2014 to May 2022 were selected as the research object by random sampling method for retrospective analysis,the esophageal variceal bleeding rate of all the patients was analyzed,and the esophageal variceal bleeding rates of patients with different gender,ages,hemoglobin level,albumin level,Child-Pugh grades,peptic ulcer,degree of esophageal varices,platelet count,ascite situation,portal vein diameter,spleen thickness,with or without gastrointestinal bleeding history and portal vein thrombosis were compared,then the influencing factors of esophageal variceal bleeding patients with posthepatitic cirrhosis were analyzed with multifactor logistic regression analysis.Result:There were 61 cases of esophageal variceal bleeding in 225 patients with posthepatitic cirrhosis,with an incidence of 27.11%.The esophageal variceal bleeding rates of patients with different gender,ages and spleen thickness were compared,the differences were not statistically significant(P>0.05),the incidences of esophageal variceal bleeding in patients with hemoglobin level<110 g/L,albumin level<30 g/L,Child-Pugh grade B and C,peptic ulcer,esophageal varices diameter>6 mm,platelet count<100×10^(9)/L,ascites,portal vein diameter≥1.5 cm,history of gastrointestinal bleeding and portal vein thrombosis were significantly higher than those in other patients,the differences were statistically significant(P<0.05),the multifactor logistic regression analysis showed the hemoglobin level,albumin level,Child-Pugh grade,peptic ulcer,degree of esophageal varices,platelet count,ascite,portal vein diameter,history of gastrointestinal bleeding and portal vein thrombosis were the influencing factors of esophageal variceal bleeding patients with posthepatitic cirrhosis(P<0.05).Conclusion:The esophageal variceal bl

关 键 词：肝炎后肝硬化 食管静脉曲张 影响因素 

分 类 号：R575.2[医药卫生—消化系统]