Oxidative stress in male infertility and therapeutic approach: A mini-review  

作　　者：Marwa Lahimer Henda Mustapha Véronique Bach Hafida Khorsi-Cauet Moncef Benkhalifa Mounir Ajina Habib Ben Ali 

机构地区：[1]Service of Reproductive Medicine,University Hospital Farhat Hached,Sousse,Tunisia [2]Exercise Physiology and Physiopathology:from Integrated to Molecular“Biology,Medicine and Health”(Code:LR19ES09),Sousse,Tunisia [3]Péritox(UMR_I 01),UPJV/INERIS,UPJV,CURS,Chemin de Thil 80025 Amiens,France [4]ART and Reproductive Biology Laboratory,University Hospital and School of Medicine,Picardie University Jules Verne,CHU Sud,80054,Amiens,France [5]Laboratory Histology Embryology,Faculty of Medicine Sousse,University of Sousse,Sousse,Tunisia

出　　处：《Asian pacific Journal of Reproduction》2023年第6期249-255,共7页亚太生殖杂志（英文版）

摘　　要：Growing evidence suggests that oxidative stress is a major cause of male infertility.Spermatozoa are highly sensitive cells due to the vulnerability of their membrane fatty acids and the diminished antioxidant defense.Reactive oxygen species(ROS)impact multiple signaling pathways involved in mitochondrial dysfunction,hormonal unbalance and semen quality decline.The origin of ROS is diverse,including generated normal cellular metabolism,environmental exposure,advanced paternal age and inflammation.Research has indicated that antioxidant supplementation can improve oxidative stress and reduce the risk of chronic diseases.Moreover,it is widely known that antioxidant supplementation can enhance sperm quality and increase the pregnancy rate in couples undergoing fertility treatments.The current study highlights the deleterious effect of ROS and its impact on semen function.In addition,it contributes to the development of a clinical approach for the use of antioxidants in the management of male infertility.

关 键 词：Oxidative stress Reactive oxygen species MITOCHONDRIA Antioxidant supplementation SPERMATOZOA 

分 类 号：R69[医药卫生—泌尿科学]