神经系统副肿瘤综合征相关自身抗体的临床应用现状与前景展望  

Current and prospective clinical applications of autoantibodies associated with paraneoplastic neurological syndromes

作　　者：白舟 刘昱东 Bai Zhou;Liu Yudong(The Key Laboratory of Geriatrics,Beijing Institute of Geriatrics,Beijing Hospital,National Center of Gerontology,National Health Commission,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院国家老年医学中心,国家卫生健康委北京老年医学研究所,国家卫生健康委老年医学重点实验室,中国医学科学院老年医学研究院,北京100730

出　　处：《中华检验医学杂志》2023年第11期1145-1148,共4页Chinese Journal of Laboratory Medicine

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-047);国家自然科学基金(81971521,82171778)。

摘　　要：神经系统副肿瘤综合征(PNS)是由肿瘤通过远隔效应引起的累及神经系统的自身免疫综合征。PNS诊断困难,PNS相关自身抗体对于疾病诊断、分层分型和个体化治疗有重要作用。PNS相关自身抗体根据其对肿瘤预测风险的能力分为高风险、中风险和低风险抗体,其实验室检测主要通过间接免疫荧光法、免疫组织化学分析、免疫印迹等方法。正确应用和解读抗体的检测结果对于PNS的诊疗至关重要。本文针对PNS相关自身抗体的临床应用现状及未来展望进行评述。Paraneoplastic neurological syndrome(PNS)is an autoimmune syndrome involving the nervous system caused by tumors through distant effects.The diagnosis of PNS is difficult,and PNS-associated autoantibodies are crucial for disease diagnosis,classification,and individualized treatment.PNS-associated autoantibodies are classified into high-,intermediate-,and low-risk antibodies based on their predictive risk of tumors.Their laboratory detection is mainly carried out through indirect immunofluorescence,immunohistochemical analysis,immunoblotting,and other methods.The correct application and interpretation of antibody detection results is crucial for the diagnosis and treatment of PNS.This article reviews the current status and future prospects of the clinical application of autoantibodies related to PNS.

关 键 词：神经系统副肿瘤综合征 自身抗体 诊断 治疗 预后 

分 类 号：R730.6[医药卫生—肿瘤] R747.9[医药卫生—临床医学]