海洋链霉菌次级代谢产物研究进展  

Research Progress on Secondary Metabolites of Marine Streptomyces

作　　者：陈巧莉 黄杰 陈森瑜 潘少婷 唐灵芝 洪璇 CHEN Qiaoli;HUANG Jie;CHEN Senyu;PAN Shaoting;TANG Lingzhi;HONG Xuan(Xiamen Key Laboratory of Marine Medicinal Natural Products Resources,Xiamen Medical College,Fujian Xiamen 361023,China;Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources,Xiamen Medical College,Fujian Xiamen 361023,China;School of Pharmacy and Pharmaceutical Sciences,Xiamen Medical College,Fujian Xiamen 361023,China)

机构地区：[1]厦门医学院,厦门市海洋药用天然产物资源重点实验室,福建厦门361023 [2]厦门医学院,海洋生物医药资源福建省高校工程研究中心,福建厦门361023 [3]厦门医学院药学系,福建厦门361023

出　　处：《生物技术进展》2023年第6期844-852,共9页Current Biotechnology

基　　金：国家级大学生创新创业训练计划项目(202312631001);福建省自然科学基金面上项目(2022J011401);厦门市自然科学基金面上项目(3502Z20227227);福建省大学生创新创业训练计划项目(S202212631006);福建省本科高校教育教学改革研究项目(FBJG20190201);厦门医学院校级科研项目(K2023-25)。

摘　　要：链霉菌作为最高等的放线菌,广泛分布于多种生态环境中,具有复杂而独特的形态分化周期和强大的次级代谢能力。链霉菌的次级代谢产物具有抗感染、抗肿瘤、抗炎抗氧化、免疫调节等生物活性,是天然活性产物的主要来源之一。近年来随着对海洋资源的开发,许多新型的海洋链霉菌及其丰富的次级代谢产物被发现。从海洋链霉菌的生物活性物质、育种和发酵培养3个方面综述了海洋链霉菌次级代谢产物的研究进展,以期为缩短海洋链霉菌的发酵周期,提高次级代谢产物产量活性以及开发新型的海洋药物等提供参考和借鉴。Streptomyces is widely distributed in various ecological environments as the most advanced actinomycete.It has complex and unique morphological differentiation cycles and strong secondary metabolic abilities.Secondary metabolites of Streptomyces have many biological activities such as anti-infection,anti-tumor,anti-inflammatory and anti-oxidant,immune adjustment and other biological activities,which is one of the main sources of natural active products.In recent years,with the development of marine resources,many new types of marine Streptomyces and their rich secondary metabolites have been discovered.The research on secondary metabolites of marine Streptomyces was reviewed,and the bioactive substances,breeding and fermentation culture of marine Streptomyces were summarized,in order to provide reference and help in shortening the fermentation cycle of marine Streptomyces,improving the yield and activity of secondary metabolites,and developing new marine drugs.

关 键 词：海洋链霉菌 次级代谢产物 生物活性 

分 类 号：Q935[生物学—微生物学] TQ920.1[轻工技术与工程—发酵工程]