以甲状腺毒性周期性麻痹为首发表现的垂体促甲状腺细胞腺瘤:1例报告  

Thyrotroph adenoma with thyrotoxic periodic paralysis as the initial symptom:one case report

作　　者：廖宇[1] 张世蕾[2] 王宇[3] LIAO Yu;ZHANG Shi-lei;WANG Yu(Department of Endocrinology and Metabolism,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Pathology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Neurosurgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院内分泌科,上海200127 [2]上海交通大学医学院附属仁济医院病理科,上海200127 [3]上海交通大学医学院附属仁济医院神经外科,上海200127

出　　处：《复旦学报（医学版）》2023年第6期935-938,共4页Fudan University Journal of Medical Sciences

基　　金：上海市闵行区卫健委基金(2019MW31)。

摘　　要：垂体促甲状腺细胞腺瘤是一类临床罕见的垂体腺瘤。本文报道1例以甲状腺毒性周期性麻痹(thyrotoxic periodic paralysis,TPP)为首发临床表现的患者,检查发现低钾血症,合并甲状腺激素明显升高伴促甲状腺激素(thyroid stimulating hormone,TSH)水平未被抑制,MRI提示垂体腺瘤,诊断为垂体促甲状腺细胞腺瘤。使用生长抑素类似物奥曲肽,术前准备后进行神经内镜下手术治疗,术后患者甲状腺功能恢复正常水平,垂体MRI未见肿瘤残留和复发。Thyrotroph adenoma is a rare clinical subtype of pituitary adenoma.This article reports a case of a patient presenting with thyrotoxic periodic paralysis(TPP)as the initial clinical manifestation.The examination revealed hypokalemia,significantly elevated thyroid hormone levels with unsuppressed thyroid stimulating hormone(TSH)levels,and MRI suggesting a pituitary adenoma.The diagnosis was confirmed as a thyrotroph adenoma.Preoperative preparation was conducted using a somatostatin analogue,octreotide,followed by neuroendoscopic surgery.The patient's thyroid function returned to normal levels after surgery,and there was no residual tumor or recurrence observed on MRI.

关 键 词：甲状腺毒性周期性麻痹(TPP) 促甲状腺细胞腺瘤 生长抑素类似物 甲状腺功能 

分 类 号：R736.1[医药卫生—肿瘤]