基于“菌-肠-脑”轴探讨帕金森病“土虚木揺”的病机  

To explore the pathogenesis of parkinson's disease of"soil deficiency and wood shake"based on the"bacteriagut-brain"axis

作　　者：张蕾蕾[1] 刘志军 金华[3] Zhang Leilei;Liu Zhijun;Jin Hua(Centers for Disease Control and Prevention of Lanzhou,Lanzhou 730000,Gansu,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州市疾病预防控制中心,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000 [3]甘肃中医药大学,甘肃兰州730000

出　　处：《中国中西医结合急救杂志》2023年第4期392-396,共5页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：甘肃省高等学校协同创新团队项目(2017C-14);甘肃省中医药科研课题(GZK-2019-24)。

摘　　要：帕金森病是一种神经系统变性疾病,显著特征是脑内多巴胺的缺乏或减少,病因和发病机制复杂,至今尚未彻底明确。中医学对帕金森病的认识详于肝肾而略于脾胃,现从“脾阴”出发,提出“土虚木揺”是帕金森病的病机特征,并从“菌-肠-脑”轴进行了分析,指出帕金森病治疗中需要“肝脾同治”。Parkinson's disease is a neurodegenerative disease characterized by a lack or reduction of dopamine in the brain.The etiology and pathogenesis are complex and have not been thoroughly clarified.The understanding of traditional Chinese medicine is detailed in the liver and kidney but slightly in the spleen and stomach.Based on the theory of"spleen yin",this article puts forward that"soil deficiency and wood shake"is the pathogenic characteristics of Parkinson's disease,analyzes this viewpoint from the"bacteria-gut-brain"axis,also points out that the simultaneous treatment of liver and spleen is needed in the intervention of Parkinson's disease.

关 键 词：帕金森病 “菌-肠-脑”轴 土虚木揺 肝脾同治 

分 类 号：R742.5[医药卫生—神经病学与精神病学]