天然小分子保护炎症性肠病中肠上皮紧密连接屏障的研究进展  

Advances in the study of natural small molecules to protect the intestinal epithelial tight junction barrier in inflammatory bowel disease

作　　者：钟玉婷 王志斌 张立超[1] ZHONG Yu-ting;WANG Zhi-bin;ZHANG Li-chao(Dept of Parmacy Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Dept of Critical Care Medicine,School of Anesthesiology,Naval Medical University,Shanghai 200433,China)

机构地区：[1]上海中医药大学附属市中医医院药学部,上海200071 [2]海军军医大学麻醉系危重病医学教研室,上海200433

出　　处：《中国药理学通报》2023年第12期2205-2210,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81973551);上海市卫健委科研项目[No ZY(2021-2023)-0203-04]。

摘　　要：炎症性肠病作为一种特发性肠道炎症疾病,可累及直肠、结肠和回肠等部位,主要包括克罗恩病和溃疡性结肠炎,其发病机制至今未明。肠黏膜上皮屏障损伤所导致的肠道通透性增加是肠道炎症启动的始动因素。肠黏膜上皮屏障的抗通透性是由肠上皮细胞顶端区域的紧密连接来维持的,紧密连接结构的破坏与炎症性肠病的发生和肠上皮屏障损伤密切相关。因此,以紧密连接为调控靶标寻找炎症性肠病的防治药物意义重大。近年来,大量天然产物来源的小分子被报道具有改善炎症性肠病的作用,该文特别针对其中具有修复肠上皮屏障功能和保护紧密连接的化合物进行综述,以期为炎症性肠病防治新药的设计和开发提供研究思路。Inflammatory bowel disease(IBD),as an idiopathic inflammatory disease of the intestinal tract,consisting mainly of Crohn's disease and ulcerative colitis,which can involve the rectum,colon and ileum,and whose pathogenesis is still not fully understood.The initiation of intestinal inflammation associated with IBD and its chronicity begins with increased intestinal permeability caused by intestinal epithelial barrier disruption.The anti-permeability of the intestinal epithelial barrier is maintained by tight junction in the apical region of the intestinal epithelial cells,and disruption of the tight junction structure is closely associated with intestinal epithelial barrier damage and the development of IBD.Therefore,it is significant to find drugs for the prevention and treatment of IBD using tight junctions as regulatory targets.In recent years,many small molecules of natural product origin have been reported to improve the effects of IBD.In particular,we review the compounds that have the function of repairing intestinal epithelial barrier and protecting tight junction structure,in order to provide research ideas for the design and development of new drugs for the prevention and treatment of IBD.

关 键 词：炎症性肠病 肠上皮屏障 紧密连接 天然小分子化合物 肠上皮细胞 肠道通透性 

分 类 号：R-05[医药卫生] R284.1R322.45R333.3R574