阿尔茨海默病与帕金森病痴呆神经心理量表的对比观察  

ComParative observation of Alzheimer's Disease and Parkinson's Disease Dementia NeuroPsychological Scale

作　　者：刘婷[1] 李丹[1] 张燕[1] 张玉洁[1] 孟新玲 Ting LIU;Dan LI;Yan ZHANG;Yujie ZHANG(Department of Encephalopathy,Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000)

机构地区：[1]新疆医科大学附属中医医院脑病科,新疆乌鲁木齐830000 [2]不详

出　　处：《阿尔茨海默病及相关病杂志》2023年第4期291-295,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：新疆维吾尔自治区科学技术厅中央引导地方科技发展专项资金项目编号:ZYD2022C17。

摘　　要：目的:本研究旨在通过神经心理量表评估阿尔茨海默病(AD)和帕金森病痴呆(PDD)患者的认知功能和精神行为,并分析两组之间的差异。方法:选取本院2016年1月至2019年12月收治的79例AD患者(AD组)和43例PDD患者(PDD组),采用神经心理量表(MMSE、MoCA、ADL、CNPI、CDR)评估两组患者的认知功能、精神行为症状,并比较两组之间的差异。结果:比较两组轻度痴呆患者间MMSE、CDR、ADL总分,差异无统计学意义(P>0.05)。而AD组的MOCA评分较PDD组更高,PDD组的CNPI评分则高于AD组(P<0.05)。在命名、语言等五个维度的评分方面,组间差异无统计学意义(P>0.05);然而在执行功能/视空间维度的评分PDD组低于AD组,在记忆力评分维度则是AD组更低(P<0.05)。两组在妄想、激越、食欲进食障碍发生率等八个维度的比较结果显示,差异均无统计学意义(P>0.05)。PDD组患者比AD组患者更容易发生幻觉,而焦虑、易激惹和淡漠的发生率较低(P<0.05)。结论:AD组的记忆力损害更明显,精神行为症状更多表现为焦虑、淡漠、易激惹,而PDD患者的执行功能和视空间功能损伤更为严重,精神行为症状以幻觉为主要表现。Objective:This study aimed to evaluate the cognitive function and Psychiatric behavior of Patients with Alzheimer's disease(AD)and Parkinson's disease dementia(PDD)using neuroPsychological scales,and to analyze the differences between the two grouPs.Methods:total of 79 AD Patients(AD grouP)and 43 PDD Patients(PDD grouP)admitted to our hosPital from January 2016 to December 2019 were selected.NeuroPsychological scales including MMSE(Mini-Mental State Examination),MoCA(Montreal Cognitive Assessment),ADL(Activities of Daily Living),CNPI(Chinese NeuroPsychiatric Inventory),and CDR(Clinical Dementia Rating)were used to assess the cognitive function and Psychiatric behavior symPtoms of the two grouPs of Patients,and the differences between the two grouPs were comPared.Results:There were no significant differences in MMSE,CDR and ADL scores between the two grouPs(P<0.05).The MOCA score of the AD grouP was higher than that of the PDD grouP,and the CNPI score of the PDD grouP was higher than that of the AD grouP(P<0.05).There was no significant difference between grouPs in the scoring of five dimensions such as naming and language(P>0.05).However,the PDD grouP was lower in the PDD grouP and lower in the AD grouP in the memory score grouP(P<0.05).The comParison results of the two grouPs in six dimensions such as delusions and the incidence of aPPetite and eating disorders showed that the differences were not statistically significant(P>0.05).Patients in the PDD grouP were more likely to hallucinate than those in the AD grouP,and the incidence of anxiety,irritability,and aPathy was lower(P<0.05).Conclusion:AD Patients showed more Pronounced memory imPairment and Psychiatric symPtoms of anxiety,aPathy,and irritability,while PDD Patients exhibited more severe imPairments in executive function and visuosPatial ability,with hallucinations being the Predominant Psychiatric symPtom.

关 键 词：阿尔茨海默病 帕金森病痴呆 认知功能 精神行为 神经心理 

分 类 号：R749.1[医药卫生—神经病学与精神病学]