小胶质细胞及星形胶质细胞在阿尔茨海默病发生发展中的作用  

The role of microglia and astrocytes in the occurrence and development of Alzheimer's disease

作　　者：王楠 孙莹 王瑞婷[1] Nan WANG;Ying SUN;Ruiting WANG(Chengde Medical College,Hebei Chende 067000)

机构地区：[1]承德医学院,河北承德067000

出　　处：《阿尔茨海默病及相关病杂志》2023年第4期326-330,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：河北省教育厅高等学校科学技术研究项目(ZD2017002);承德医学院神经生物学学科(071006);河北省中医药重点学科建设项目(冀中医药函[2021]7号)。

摘　　要：阿尔茨海默病(AD)是以记忆障碍和认知能力下降为特征的一种进行性神经变性疾病,最终影响言语、行为、视觉空间定位和运动系统。Aβ沉积到一定剂量将启动一些机制引起病理改变,导致记忆力下降。在众多机制中炎症反应起着重要作用。近年来的研究发现,小胶质细胞和星形胶质细胞的活化可以促进神经炎症反应,造成神经元损伤。本文从小胶质细胞及星形胶质细胞方面对AD的作用影响及中药调控神经炎症治疗AD进行系统性的整理和归纳,为AD的治疗及进一步的研究提供一定的理论参考依据。Alzheimer's Disease(AD)is a progressive neurodegenerative disease characterized by memory impairment and cognitive decline,which ultimately affects speech,behavior,visual spatial localization and motor system.The deposition of Aβto a certain dose will initiate some mechanisms to cause pathological changes and lead to memory loss.Oxidative stress and inflammation play important roles in many mechanisms.In recent years,it has been found that the activation of microglia and astrocytes can promote neuroinflammatory response and cause neuronal damage.This paper systematically collates and summarizes the effects of microglia and astrocytes on AD and the regulation of traditional Chinese medicine on neuroinflammation in the treatment of AD,in order to provide some theoretical reference for the treatment and further research of AD.

关 键 词：阿尔茨海默病 小胶质细胞 星形胶质细胞 Β-淀粉样蛋白 发病机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]