神经变性疾病与日间过度嗜睡  

Neurodegenerative diseases and excessive daytime sleepiness

作　　者：任娟[1,2] 刘蕊 唐诗 杜怡峰[1,2,3] Juan REN;Rui LIU;Shi TANG;Yifeng DU(Shandong University,Jinan 250100,China;Department of Neurology,Shandong Provincial Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250021,China;Department of Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong,China;Department of Ultrasound,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong,China)

机构地区：[1]山东大学,济南250100 [2]山东大学附属省立医院神经内科,济南250021 [3]山东第一医科大学附属省立医院神经内科,济南250021 [4]山东第一医科大学附属省立医院超声科,济南250021

出　　处：《阿尔茨海默病及相关病杂志》2023年第4期331-336,共6页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：国家重点研发计划项目(项目编号:2017YFC1310100);国家自然科学基金资助项目(项目编号:81861138008);国家自然科学基金资助项目(项目编号:82011530139);国家自然科学基金资助项目(项目编号:82001397);山东省济南市科技计划项目(项目编号:202019187);中国科协青年人才托举工程(项目编号:YESS20200362)。

摘　　要：神经变性疾病(neurodegenerative diseases,NDD)是一类慢性进行性大脑和脊髓的细胞神经元变性、凋亡而导致的疾病的总称。NDD常出现睡眠障碍,常见的有日间过度嗜睡(excessive daytime sleepiness,EDS),而EDS也可以作为NDD发生的预测因子,目前二者之间的机制尚不明。文中通过对NDD与EDS的发病机制、病理生理研究、诊断及治疗等进行综述,以期为今后研究方向提供新视野。Neurodegenerative disease is a kind of chronic progressive disease,which is characterized by the loss of neurons in the nervous system and the abnormal deposition of proteins in living cells.Sleep disorders often occur in neurodegenerative diseases,such as excessive daytime sleepiness(EDS),and EDS can also be used as a predictor of neurodegenerative diseases.The mechanism between them is still unknown at present.According to the research in recent years,this paper reviews the pathogenesis,pathophysiology,diagnosis and treatment of neurodegenerative disease and EDS,so as to provide a new field of vision for the related diseases.

关 键 词：神经变性疾病 日间过度嗜睡 帕金森病 路易体痴呆 多系统萎缩 阿尔茨海默病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]