血清LCN2、Apelin-17水平与急性缺血性卒中患者侧支循环形成的关系  

Relationships between serum LCN2 and Apelin-17 levels and formation of collateral circulation in patients with acute ischemic stroke

作　　者：范志伟[1] 谢振林[1] 毕正强 FAN Zhiwei;XIE Zhenlin;BI Zhengqiang(Department of Emergency Medicine,Jiangbei Hospital,Zhongda Hospital Affiliated to Southeast University,Nanjing 210044,China)

机构地区：[1]东南大学附属中大医院江北院区急诊医学科,南京210044

出　　处：《山东医药》2023年第34期21-25,共5页Shandong Medical Journal

基　　金：江苏省医学科研项目(JH19090)。

摘　　要：目的探讨血清脂质运载蛋白2(LCN2)、血管紧张素Ⅱ受体样1内源性配体17(Apelin-17)水平与急性缺血性卒中(AIS)患者侧支循环形成的关系。方法选取181例AIS患者为AIS组,根据侧支循环形成情况分为不良组69例和良好组112例,另选取60例体检健康者为对照组。采用酶联免疫吸附法检测血清LCN2、Apelin-17。采用多因素Logistic回归分析AIS患者侧支循环形成不良的影响因素,采用受试者工作特征(ROC)曲线分析血清LCN2、Apelin-17水平对AIS患者侧支循环形成不良的预测价值。结果与对照组比较,AIS组血清LCN2水平升高,Apelin-17水平降低(P均<0.05)。多因素Logistic回归分析显示,年龄大(OR=1.048,95%CI:1.010~1.087)、高血压(OR=2.052,95%CI:1.034~4.072)、糖尿病(OR=2.127,95%CI:1.115~4.056)、美国国立卫生研究院卒中量表评分高(OR=1.166,95%CI:1.049~1.296)、LCN2水平高(OR=1.225,95%CI:1.127~1.331)为AIS患者侧支循环形成不良的独立危险因素,Apelin-17水平高(OR=0.947,95%CI:0.926~0.969)为独立保护因素(P均<0.05)。ROC曲线分析显示,血清LCN2联合Apelin-17(AUC=0.861,95%CI:0.802~0.908)预测AIS患者侧支循环形成不良的曲线下面积(AUC)大于LCN2(AUC=0.764,95%CI:0.696~0.824)、Apelin-17(AUC=0.765,95%CI:0.697~0.825)单独预测(P均<0.05)。结论血清LCN2水平升高和Apelin-17水平降低与AIS患者侧支循环形成不良独立相关,血清LCN2联合Apelin-17预测AIS患者侧支循环形成不良的价值较高。Objective To investigate the relationships between serum lipid transport protein 2(LCN2)and Angio⁃tensinⅡreceptor-like 1 endogenous ligand 17(Apelin-17)levels and the formation of collateral circulation in patients with acute ischemic stroke(AIS).Methods Totally 181 patients with AIS were selected as the AIS group,and were di⁃vided into the poor group of 69 cases and the good group of 112 cases according to the formation of collateral circulation,and another 60 healthy physical examiners were selected as the control group.Serum LCN2 and Apelin-17 levels were mea⁃sured by enzyme-linked immunosorbent assay.Multi-factor Logistic regression was used to analyze the factors influencing the poor formation of collateral circulation in AIS patients,and receiver operating characteristic(ROC)curves were used to analyze the predictive value of serum LCN2 and Apelin-17 levels on the poor formation of collateral circulation in AIS pa⁃tients.Results Compared with the control group,serum LCN2 level increased and Apelin-17 level decreased in the AIS group(both P<0.05).Multifactorial Logistic regression analysis showed that age(OR=1.048,95%CI:1.010 to 1.087),hypertension(OR=2.052,95%CI:1.034 to 4.072),diabetes mellitus(OR=2.127,95%CI:1.115 to 4.056),national institutes of health stroke scale score(OR=1.166,95%CI:1.049 to 1.296),and LCN2(OR=1.225,95%CI:1.127 to 1.331)were independent risk factors for poor collateral circulation formation,and Apelin-17(OR=0.947,95%CI:0.926 to 0.969)was an independent protective factor(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum LCN2 combined with Apelin-17(AUC=0.861,95%CI:0.802 to 0.908)in predicting poorly formed collateral circulation was greater than that of LCN2(AUC=0.764,95%CI:0.696 to 0.824)or Apelin-17(AUC=0.765,95%CI:0.697 to 0.825)alone(both P<0.05).Conclusion Increased serum LCN2 levels and decreased Ape⁃lin-17 levels were independently associated with poor collateral circulation formation in patients with AIS,and serum LCN2 combined with Ap

关 键 词：急性缺血性卒中 侧支循环 脂质运载蛋白2 血管紧张素Ⅱ受体样1内源性配体17 

分 类 号：R743[医药卫生—神经病学与精神病学]