复方消化酶胶囊联合多潘立酮对功能性消化不良的疗效及相关炎症因子的影响  

Effect of Compound Digestive Enzyme Capsules combined with Domperidone on functional dyspepsia and related inflammatory factors

作　　者：周卉 林武广 周莉玲 ZHOU Hui;LIN Wuguang;ZHOU Liling(Department of Medical Teaching and Research,Shangrao Health School,Jiangxi Province,Shangrao 334600,China;Department of Gastroenterology,Guangfeng District Traditional Chinese Medicine Hospital,Jiangxi Province,Shangrao 334600,China;Department of Internal Medicine,Guangfeng District People's Hospital,Jiangxi Province,Shangrao 334600,China)

机构地区：[1]上饶卫生学校医学教研室,江西上饶334600 [2]江西省上饶市广丰区中医院消化内科,江西上饶334600 [3]江西省上饶市广丰区人民医院内科,江西上饶334600

出　　处：《中国当代医药》2023年第33期58-61,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202140963)。

摘　　要：目的探讨复方消化酶胶囊联合多潘立酮对功能性消化不良(FD)的疗效及相关炎症因子的影响。方法选取2020年1月至2022年12月的上饶卫生学校附属医院、广丰区中医院、广丰区人民医院收治的60例FD患者作为研究对象,采用随机数字表法将其分为对照组和研究组,每组各30例。对照组给予多潘立酮片,研究组在对照组的基础上加用复方消化酶胶囊。比较两组患者的临床症状积分、临床疗效、临床症状消失时间、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、血清学指标[促肾上腺皮质激素释放激素(CRH)、胃动素(MTL)、胃泌素-17(G-17)、血清胃蛋白酶原(PG)]水平和不良反应发生率。结果治疗后,两组患者的临床症状积分低于本组治疗前,且研究组积分低于对照组,差异有统计学意义(P<0.05)。研究组的总有效率高于对照组,差异有统计学意义(P<0.05)。研究组的食欲减退消失、上腹痛消失、早饱消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组的IL-6、TNF-α水平低于本组治疗前,且研究组各项水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的CRH低于本组治疗前,且研究组CRH水平低于对照组,两组的MTL、G-17、PG水平高于本组治疗前,且研究组MTL、G-17、PG水平高于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未出现严重不良反应。结论复方消化酶胶囊联合多潘立酮用于FD治疗可有效降低炎症因子水平,促进胃肠功能的恢复,利于减轻消化不良症状,且用药安全性较高,值得在临床推广应用。Objective To investigate the effect of Compound Digestive Enzyme Capsules combined with Domperidone on functional dyspepsia(FD)and the influence of related inflammatory factors.Methods A total of 60 FD patients admitted to the Affiliated Hospital of Shangrao Health School,Guangfeng District Traditional Chinese Medicine Hospital and Guangfeng District People's Hospital from January 2020 to December 2022 were selected as research objects,and they were divided into the control group and the study group by random number table method,with 30 cases in each group.The control group was given Domperidone Tablets,and the study group was given Compound Digestive Enzyme Capsules on the basis of the control group.Clinical symptom scores,clinical efficacy,duration of clinical symptom resolution,levels of inflammatory factors(interleukin-6[IL-6],tumor necrosis factor-α[TNF-α]),serological indicators(corticotrophin releasing hormone[CRH],motilin[MTL],gastrin-17[G-17],serum pepsinogen[PG])levels and incidence of adverse reactions were compared between the two groups.Results After treatment,the clinical symptom scores of the two groups were lower than those before treatment,and the score of the study group was lower than that of the control group,the differences were statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The disappearance time of appetite loss,upper abdominal pain and early satiety in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of IL-6 and TNF-αin the two groups were lower than those before treatment,and the levels of study group was lower than the control group,with statistical significance(P<0.05).After treatment,CRH in both groups were lower than those before treatment,and CRH in the study group was lower than that in the control group,the levels of MTL,G-17 and PG in the two groups were

关 键 词：功能性消化不良 复方消化酶胶囊 多潘立酮 炎症因子 胃动力学指标 

分 类 号：R57[医药卫生—消化系统]