单核细胞与高密度脂蛋白胆固醇比值、白介素-6在非酒精性脂肪性肝病中的临床价值  

Clinical value of monocyte to high density lipoprotein cholesterol ratio and interleukin-6 in non-alcoholic fatty liver disease

作　　者：张仕佩 邵一帆 薄春燕[2] ZHANG Shipei;SHAO Yifan;BO Chunyan(Department of Clinical Laboratory,Jiujiang No.1 People's Hospital,Jiangxi Province,Jiujiang 332000,China;Department of Nutrition,Jiujiang No.1 People's Hospital,Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院检验科,江西九江332000 [2]江西省九江市第一人民医院营养科,江西九江332000

出　　处：《中国当代医药》2023年第33期119-122,127,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(SKJP220200272)。

摘　　要：目的探讨单核细胞与高密度脂蛋白胆固醇比值(MHR)和白介素-6(IL-6)在非酒精性脂肪性肝病(NAFLD)中的临床价值。方法选取2020年10月至2021年3月在九江市第一人民医院健康管理中心的88名体检者为研究对象,其中60例NAFLD患者为NAFLD组,28例健康者为对照组。分析NAFLD组与对照组谷丙转氨酶(ALT)、谷草转氨酶(AST)、空腹血糖(FPG)、三酰甘油(TC)、总胆固醇(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、嗜中性粒细胞(NEU)、淋巴细胞(LYM)、单核细胞(MONO)、体重指数(BMI)、MHR、IL-6的检测值,绘制受试者工作特征(ROC)曲线分析MHR、IL-6对NAFLD的诊断价值。结果两组的AST、TG、LDL-C、NEU、LYM、ALT、FPG、TC、HDL-C、MONO、BMI、IL-6和MHR检测水平比较,差异有统计学意义(P<0.05);NAFLD组中,按脂肪肝严重程度分为轻度脂肪肝组、中度脂肪肝组和重度脂肪肝组,三组的年龄、性别、FPG、TC、LDL-C、NEU、MONO检测值比较,差异无统计学意义(P>0.05),三组的ALT、AST、TG、HDL-C、LYM、BMI、MHR和IL-6检测水平比较,差异有统计学意义(P<0.05)。ROC曲线显示,MHR、IL-6诊断NAFLD的曲线下面积分别为0.773,0.796,联合检测时曲线下面积为0.807。结论MHR作为新型生物标志物,获得方便,在NAFLD诊断预测准确性较高,可给临床预后疗效、特异性和敏感性随访,治疗,动态监测方面提供新的检查方法和思路。Objective To investigate the clinical value of monocyte to high density lipoprotein cholesterol ratio(MHR)and interleukin-6(IL-6)in non-alcoholic fatty liver disease(NAFLD).Methods A total of 88 patients who underwent physical examination in the Health Management Center of Jiujiang No.1 People's Hospital from October 2020 to March 2021 were selected as the study objects,including 60 patients with NAFLD as the NAFLD group and 28 healthy people as the control group.Alanine aminotransferase(ALT),aspartate aminotransferase(AST),fasting plasma glucose(FPG),triacylglycerol(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),neutrophil(NEU)and lymphocyte(LYM),monocytes(MONO),body mass index(BMI),MHR and IL-6 were detected and analyzed in NAFLD group and control group.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of MHR and IL-6 in NAFLD.Results There were significant differences in AST,TG,LDL-C,NEU,LYM,ALT,FPG,TC,HDL-C,MONO,BMI,IL-6 and MHR between the NAFLD group and the normal control group(P<0.05).NAFLD group was divided into mild fatty liver group,moderate fatty liver group and severe fatty liver group according to the severity of fatty liver.There was no significant difference in age,sex,FPG,TC,LDL-C,NEU,MONO detection values among the three groups(P>0.05).There were statistically significant differences in ALT,AST,TG,HDL-C,LYM,MHR,IL-6 and BMI among the three groups(P<0.05).ROC curve showed that the area under the curve of MHR and IL-6 in diagnosing NAFLD was 0.773 and 0.796,respectively,and the area under the curve was 0.807 in the combined detection.Conclusion MHR,as a novel biomarker,has high predictive accuracy for the diagnosis of NAFLD and is of great value in terms of clinical prognostic efficacy,specificity and sensitivity follow-up and treatment monitoring.

关 键 词：单核细胞 高密度脂蛋白胆固醇 白介素-6 单核细胞与高密度脂蛋白胆固醇比值 非酒精性脂肪性肝病 

分 类 号：R575.5[医药卫生—消化系统]