8项实验室指标对初诊骨痛多发性骨髓瘤患者的意义  

Significance of Eight Laboratory Indices in Patients with Multiple Myeloma at First Diagnosis of Bone Pain

作　　者：赵晓彤 高灿 陈雪茹 马雅静[1] ZHAO Xiao-tong;GAO Can;CHEN Xue-ru;MA Ya-jing(Department of clinical laboratory,the First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,832008;Shihezi University School of Medicine,Xinjiang Shihezi,832008)

机构地区：[1]石河子大学第一附属医院检验科,新疆石河子832008 [2]石河子大学医学院,新疆石河子832002

出　　处：《农垦医学》2023年第4期313-317,共5页Journal of Nongken Medicine

基　　金：2022年新疆生产建设兵团指导性科技计划立项项目(2022ZD036);新疆维吾尔自治区研究生教育创新计划项目(XJ2022G110)。

摘　　要：目的:收集分析三种病因导致骨痛患者的实验室检查结果,提高首发症状为腰痛的多发性骨髓瘤的诊断效率。方法:回顾2016年8月至2022年6月我院以腰痛为首发的多发性骨髓瘤、单纯骨质破坏病例各16例;压缩性骨折、健康人群各17例。患者入院后测定生化、血常规、血凝学指标。采用单因素方差分析、秩和检验或χ^(2)检验分析四组间的差异。结果:多发性骨髓瘤组的生化检查(总蛋白、球蛋白、胱抑素C)高于其他三组(P<0.05);生化检查(白蛋白、白球比)、血常规检查(血红蛋白、红细胞计数、红细胞压积)低于其他三组,差异有统计学意义(P<0.05)。结论:对于腰痛为首发症状但以上实验室检查指标异常的骨痛就诊患者,应考虑多发性骨髓瘤的可能,降低误诊率。Objective:To collect and analyze the laboratory results of patients with bone pain caused by three etiologies,improve the diagnostic efficiency of multiple myeloma diseases with primary symptoms like bone destruction or lumbar compression fracture.Methods:All cases of bone pain were reviewed from August 2016 to June 2022.All patients were divided into 4 groups:Group multiple myeloma(n=16);Group bone destruction(n=16);Group lumbar compression fractures(n=17);Group healthy persons(n=17).After admission,all four groups of patients were recruited from fasting venous blood to measure indexes.Observation index:One-way ANOVA,rank sum test or 2 test were used to analyze the differences between the four groups.Results:The biochemical examination(total protein,globulin,cystatin C)in the multiple myeloma group was higher than other groups(<0.05),the difference was statistically significant;The biochemical tests(albumin,white ball ratio)and blood routine tests(hemoglobin,red blood cell count,hematocrit)in the multiple myeloma group were lower than those in the bone destruction group and the lumbar compression fracture group,with a<0.05,and the difference was statistically significant.Conclusion:For patients whose primary symptoms is bone pain but the above laboratory test indicators are abnormal,the possibility of multiple myeloma should be considered,so as to reduce the possibility of misdiagnosis.

关 键 词：多发性骨髓瘤 误诊率 骨病 实验室检查指标 

分 类 号：R733.3[医药卫生—肿瘤]